Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation

Yu S Rybakova; A L Kalen; J C Eckers; T N Fedorova; P C Goswami; E H Sarsour

doi:10.18097/PBMC20156104510

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Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation

Journal article

Open access

Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation

Yu S Rybakova, A L Kalen, J C Eckers, T N Fedorova, P C Goswami and E H Sarsour

Biomedit͡s︡inskai͡a︡ khimii͡a, Vol.61(4), pp.510-518

07/2015

DOI: 10.18097/PBMC20156104510

PMID: 26350743

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Abstract

Carnosine is an endogenous dipeptide with antiproliferative properties. Here we show that carnosine selectively inhibits proliferation of human glioblastoma cells (U-118-MG) compared to breast (MB231) and oral (Cal27 and FaDu) cancer cells. Carnosine-induced inhibition of U-118-MG proliferation is associated with a significant: decrease in cellular reactive oxygen species levels, increase in manganese superoxide dismutase (MnSOD) and increase in cyclin B1 expression resulting in G2-block. We conclude that the antiproliferative property of carnosine is due to its ability to enhance MnSOD and cyclin B1 expression. These results will be of significance to the potential application of carnosine in brain cancer therapy.

Superoxide Dismutase - genetics

Reactive Oxygen Species - metabolism

Neuroglia - pathology

Humans

Cyclin B1 - genetics

Cyclin B1 - agonists

Cyclin B1 - metabolism

Carnosine - pharmacology

Organ Specificity

Neuroglia - drug effects

Dose-Response Relationship, Drug

Reactive Oxygen Species - antagonists & inhibitors

G2 Phase Cell Cycle Checkpoints - drug effects

Cell Line, Tumor

Neuroglia - metabolism

Antineoplastic Agents - pharmacology

Cell Proliferation - drug effects

Gene Expression Regulation, Neoplastic - drug effects

Superoxide Dismutase - metabolism

Details

Title: Subtitle: Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation
Creators: Yu S Rybakova - Neurology Research Center, Moscow, Russia
A L Kalen - Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, USA
J C Eckers - Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, USA
T N Fedorova - Neurology Research Center, Moscow, Russia
P C Goswami - Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, USA
E H Sarsour - Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, USA
Resource Type: Journal article
Publication Details: Biomedit͡s︡inskai͡a︡ khimii͡a, Vol.61(4), pp.510-518
Publisher: Russia (Federation)
DOI: 10.18097/PBMC20156104510
PMID: 26350743
ISSN: 2310-6972
eISSN: 2310-6905
Language: Russian
Date published: 07/2015
Academic Unit: Radiation Oncology
Record Identifier: 9984047861102771

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