Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus

Ying Rong; Wei Bao; Zhilei Shan; Jun Liu; Xuefeng Yu; Songfan Xia; Hui Gao; Xia Wang; Ping Yao; Frank B Hu; Liegang Liu

doi:10.1371/journal.pone.0073272

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Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus

Journal article

Open access

Peer reviewed

Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus

Ying Rong, Wei Bao, Zhilei Shan, Jun Liu, Xuefeng Yu, Songfan Xia, Hui Gao, Xia Wang, Ping Yao, Frank B Hu, …

PloS one, Vol.8(9), pp.e73272-e73272

2013

DOI: 10.1371/journal.pone.0073272

PMCID: PMC3759444

PMID: 24023848

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Abstract

MicroRNAs (miRNAs), a class of small non-coding RNAs, are thought to serve as crucial regulators of gene expression. Dysregulated expression of miRNAs has been described in various diseases and may contribute to related pathologic processes. Our aim was to examine circulating miRNA-146a levels in newly diagnosed type 2 diabetes mellitus (new-T2DM) patients from a Chinese Han population. Circulating miRNA-146a was extracted from plasma samples of 90 new-T2DM patients and 90 age- and sex-matched controls. Quantitative PCR assessment revealed that circulating miRNA-146a levels were significantly elevated in new-T2DM patients compared with controls. Participants in the highest tertile of circulating miRNA-146a levels showed a notably higher risk for new-T2DM (crude OR 4.333, 95% CI, 1.935 to 9.705, P = 0.001) than persons in the lowest tertile. Controlling for known risk factors and some biochemical indicators did not attenuate the aforementioned association. In addition, receiver operating characteristic (ROC) curves generated for miRNA-146a revealed an area under the curve (AUC) of 0.725 (95% CI, 0.651 to 0.799, P < 0.001). Moreover, higher circulating miRNA-146a levels were significantly associated with higher plasma heme oxygenase-1 (HO-1) concentrations (β coefficient = 0.131, P < 0.001) and lower HOMA-beta (β coefficient = -0.153, P = 0.015). We found that circulating miRNA-146a levels were significantly elevated in new-T2DM patients compared with healthy controls. Whether expression of circulating miRNA-146a holds predictive value for T2DM warrants further investigations.

Heme Oxygenase-1 - blood

Disease Susceptibility

Diabetes Mellitus, Type 2 - genetics

Humans

Middle Aged

Diabetes Mellitus, Type 2 - enzymology

Male

Case-Control Studies

Diabetes Mellitus, Type 2 - diagnosis

Asian Continental Ancestry Group

Diabetes Mellitus, Type 2 - blood

Adult

Female

ROC Curve

MicroRNAs - blood

Details

Title: Subtitle: Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus
Creators: Ying Rong - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ; Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Wei Bao
Zhilei Shan
Jun Liu
Xuefeng Yu
Songfan Xia
Hui Gao
Xia Wang
Ping Yao
Frank B Hu
Liegang Liu
Resource Type: Journal article
Publication Details: PloS one, Vol.8(9), pp.e73272-e73272
DOI: 10.1371/journal.pone.0073272
PMID: 24023848
PMCID: PMC3759444
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: United States
Language: English
Date published: 2013
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983996058702771

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