Journal article
Increased norepinephrine turnover in the median preoptic nucleus following reduced extracellular fluid volume
Brain research, Vol.423(1), pp.369-372
1987
DOI: 10.1016/0006-8993(87)90865-1
PMID: 3676814
Abstract
The role of noradrenergic input to fluid balance regulatory systems in the anterior hypothalamus was studied by examination of norepinephrine (NE) turnover during reduction of systemic extracellular fluid volume. Extracellular fluid volume was decreased iso-os-motically by subcutaneous polyethylene glycol (PEG), known to increase thirst and vasopressin secretion. NE turnover was assessed by measuring the decline of NE concentration in brain micropunches after administration of α-methyl tyrosine in PEG- or shamtreated groups. Several hypothalamic areas were investigated, including the median preoptic area (MnPO), preoptic area (POA), paraventricular nucleus, supraoptic nucleus (SON), subfornical organ, ventromedial hypothalamus, and posterior hypothalamus. Volume-depleted animals showed significantly increased NE turnover in the MnPO, an important area for integration of fluod balance information. The POA and the SON also showed trends toward increased NE turnover. All other areas showed no difference in NE turnover between volume-depleted and normal animals. These results are consistent with previous findings that NE innervation to the MnPO is important in the control of fluid balance and also support the hypothesis that basal forebrain NE projections facilitate thirst and vasopressin secretion.
Details
- Title: Subtitle
- Increased norepinephrine turnover in the median preoptic nucleus following reduced extracellular fluid volume
- Creators
- L.D Wilkin - Department of Anatomy University of Iowa, Iowa City, IA 52242, U.S.AK.P Patel - Internal Medicine University of Iowa, Iowa City, IA 52242, U.S.AP.G Schmid - Internal Medicine University of Iowa, Iowa City, IA 52242, U.S.AA.K Johnson - Department of Psychology University of Iowa, Iowa City, IA 52242, U.S.A
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.423(1), pp.369-372
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(87)90865-1
- PMID
- 3676814
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1987
- Academic Unit
- Psychological and Brain Sciences; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984213267102771
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