Journal article
Increased plasma nitric oxide, L-arginine, and arginase-1 in cirrhotic patients with progressive renal dysfunction
Journal of gastroenterology and hepatology, Vol.24(6), pp.1030-1037
2009
DOI: 10.1111/j.1440-1746.2008.05757.x
PMID: 19226382
Abstract
Background and Aims: Increased levels of nitric oxide (NO) are hypothesized to contribute to renal dysfunction in patients with decompensated cirrhosis. In this study, we examined whether splanchnic and/or peripheral NO levels and L-arginine (L-Arg) correlate with progressive renal dysfunction in cirrhotics.
Methods: Serum NO metabolites (NOx) and L-Arg were measured in: controls (n = 10); organ donors (n = 12); compensated cirrhotics (n = 17), cirrhotics with ascites (n = 25), refractory ascites (n = 11) or hepatorenal syndrome type II (HRS) (n = 11) and chronic renal failure patients (n = 18).
Results: Plasma NOx and L-Arg levels rose progressively with worsening renal function in decompensated cirrhotics. Both NOx and L-Arg levels were highest in patients with HRS (P < 0.001 and P < 0.025, respectively). While there were no differences in NOx levels related to the site of sampling, L-Arg levels were lowest in hepatic venous blood. There were significant relationships of NOx and L-Arg with Model for End-Stage Liver Disease score and Child–Pugh scores (P < 0.04 and P < 0.01, respectively). Multivariate analysis showed a significant relationship between NOx, L-Arg and HRS.
Conclusion: Worsening renal function in decompensated cirrhosis is accompanied by progressive elevation in plasma NOx and L-Arg. These findings support the hypothesis that NO-mediated vasodilation is probably linked with the mechanism of progressive renal failure in decompensated cirrhotics.
Details
- Title: Subtitle
- Increased plasma nitric oxide, L-arginine, and arginase-1 in cirrhotic patients with progressive renal dysfunction
- Creators
- Zeid KAYALI - Transplantation Institute, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesJason HERRING - Department of Biochemistry, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesRajiv SHARMA - Department of Medicine, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesMeleah MATHAHS - Research Service, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Veterans Administration Medical Center and University of Iowa Hospital and Clinics, Iowa City, Iowa, United StatesLawrance SOWERS - Department of Biochemistry, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesKyle E BROWN - Research Service, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Veterans Administration Medical Center and University of Iowa Hospital and Clinics, Iowa City, Iowa, United StatesWarren N SCHMIDT - Research Service, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Veterans Administration Medical Center and University of Iowa Hospital and Clinics, Iowa City, Iowa, United StatesPedro BARON - Transplantation Institute, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesEdson FRANCO - Transplantation Institute, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesOkechukwu OJOGHO - Transplantation Institute, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesJason SMITH - Department of Radiology, Division of Interventional Radiology, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesGregory WATKINS - Department of Radiology, Division of Interventional Radiology, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesDouglas SMITH - Department of Radiology, Division of Interventional Radiology, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesVictor LAMIN - Department of Medicine, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United StatesThanh HOANG - Department of Medicine, Loma Linda University Medical Center and Loma Linda University School of Medicine, Loma Linda, California, United States
- Resource Type
- Journal article
- Publication Details
- Journal of gastroenterology and hepatology, Vol.24(6), pp.1030-1037
- Publisher
- Wiley-Blackwell; Richmond
- DOI
- 10.1111/j.1440-1746.2008.05757.x
- PMID
- 19226382
- ISSN
- 0815-9319
- eISSN
- 1440-1746
- Language
- English
- Date published
- 2009
- Academic Unit
- Gastroenterology and Hepatology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984047714902771
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