Journal article
Increased risk of extrapyramidal side-effect treatment associated with atypical antipsychotic polytherapy
Acta psychiatrica Scandinavica, Vol.113(2), pp.135-141
Accepted for publication June 13, 2005
02/2006
DOI: 10.1111/j.1600-0447.2005.00589.x
PMID: 16423165
Abstract
Objective: To determine whether atypical antipsychotic polytherapy is a risk factor for drug treatment for extrapyramidal side-effects (anti-EPS drugs) and whether the risk is attributable to antipsychotic dose. Method: We studied Iowa Medicaid beneficiaries aged 18-64 years with an active atypical and no conventional antipsychotic on January 1, 2001. The association of atypical antipsychotic polytherapy with anti-EPS drug treatment was determined. Multiple logistic regression was utilized to adjust for covariates in two models, the first adjusting for age, sex and the specific antipsychotic(s) prescribed, and the second also adjusting for doses. Results: Among 4400 patients, the unadjusted odds of anti-EPS treatment were increased two-fold with polytherapy. Polytherapy remained a risk factor in the first model (OR 1.5, 95% CI 1.1-2.0), but not after adjusting for doses (OR 1.0, 95% CI 0.7-1.4). Conclusion: Atypical antipsychotic polytherapy is a risk factor for anti-EPS drug treatment, apparently because of higher cumulative doses.
Details
- Title: Subtitle
- Increased risk of extrapyramidal side-effect treatment associated with atypical antipsychotic polytherapy
- Creators
- R. M Carnahan - Department of Pharmacy: Clinical and Administrative Sciences, The University of Oklahoma College of Pharmacy, Tulsa, OKB. C Lund - Laureate Psychiatric Research Center, Tulsa, OKP. J Perry - Division of Clinical and Administrative Pharmacy, The University of Iowa College of Pharmacy, Iowa City, IAE. A Chrischilles - Department of Epidemiology, The University of Iowa College of Public Health, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Acta psychiatrica Scandinavica, Vol.113(2), pp.135-141
- Edition
- Accepted for publication June 13, 2005
- DOI
- 10.1111/j.1600-0447.2005.00589.x
- PMID
- 16423165
- NLM abbreviation
- Acta Psychiatr Scand
- ISSN
- 0001-690X
- eISSN
- 1600-0447
- Publisher
- Munksgaard International Publishers
- Number of pages
- 7
- Language
- English
- Date published
- 02/2006
- Academic Unit
- Pharmacy; Epidemiology; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984214849602771
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