Increased sensitivity of the elderly to the central depressant effects of diazepam

N Pomara; B Stanley; R Block; R C Berchou; M Stanley; D J Greenblatt; R E Newton; S Gershon

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Increased sensitivity of the elderly to the central depressant effects of diazepam

Journal article

Peer reviewed

Increased sensitivity of the elderly to the central depressant effects of diazepam

N Pomara, B Stanley, R Block, R C Berchou, M Stanley, D J Greenblatt, R E Newton and S Gershon

The journal of clinical psychiatry, Vol.46(5), pp.185-187

05/1985

PMID: 3988718

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Abstract

The effects of diazepam on memory and psychomotor performance in healthy elderly (N = 12) and young (N = 12) individuals were examined. Diazepam was administered acutely in a single, oral 2.5 mg dose. Diazepam impaired memory, both immediate and delayed recall, and psychomotor performance in the elderly subjects. In addition, the drug caused an increase in self-reported sedation in elderly subjects but not in young subjects. These findings suggest an age-related increase in the sensitivity of elderly individuals to the central depressant effects of diazepam.

Memory - drug effects

Age Factors

Double-Blind Method

Administration, Oral

Diazepam - administration & dosage

Diazepam - adverse effects

Humans

Middle Aged

Male

Psychomotor Performance - drug effects

Diazepam - pharmacology

Dose-Response Relationship, Drug

Placebos

Adult

Female

Aged

Details

Title: Subtitle: Increased sensitivity of the elderly to the central depressant effects of diazepam
Creators: N Pomara
B Stanley
R Block
R C Berchou
M Stanley
D J Greenblatt
R E Newton
S Gershon
Resource Type: Journal article
Publication Details: The journal of clinical psychiatry, Vol.46(5), pp.185-187
Publisher: United States
PMID: 3988718
ISSN: 0160-6689
eISSN: 1555-2101
Language: English
Date published: 05/1985
Academic Unit: Iowa Neuroscience Institute; Anesthesia
Record Identifier: 9984006319902771

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