Journal article
Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression
American journal of physiology. Heart and circulatory physiology, Vol.286(2), pp.H619-626
02/2004
DOI: 10.1152/ajpheart.00450.2003
PMID: 14715499
Abstract
Depression is an important public health problem and is considered to be an independent risk factor for coronary artery disease. The pathophysiological mechanisms that link depression with adverse cardiovascular events (e.g., myocardial ischemia, myocardial infarction, and sudden death) are not well established. It is possible that an increased susceptibility to life-threatening cardiac arrhythmias in depressed patients influences the risk of morbidity and mortality in coronary artery disease. This idea was tested with the use of an experimental model of depression that was developed to induce anhedonia, the reduced responsiveness to pleasurable stimuli observed in human depressed patients. Rats exposed to 4 wk of chronic mild stress (e.g., paired housing, strobe light, and white noise) displayed anhedonia, which was operationally defined by the reduced intake of a palatable sucrose solution relative to an established baseline and to control animals. Furthermore, compared with control rats, the anhedonic rats showed increased basal heart rate and decreased heart rate variability. In response to an intravenously infused chemical challenge, aconitine, anhedonic rats exhibited an increased vulnerability to ventricular arrhythmias, as indicated by a reduced threshold for premature ventricular complexes, salvos, and ventricular tachycardia. These findings suggest that the presence of depressive symptoms is associated with a lower threshold for ventricular arrhythmias, which may contribute to the increased risk for adverse cardiovascular events in patients with depression.
Details
- Title: Subtitle
- Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression
- Creators
- Angela J Grippo - Department of Psychology, University of Iowa, Iowa City 52242-1407, USAClaudia M SantosRalph F JohnsonTerry G BeltzJames B MartinsRobert B FelderAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.286(2), pp.H619-626
- Publisher
- United States
- DOI
- 10.1152/ajpheart.00450.2003
- PMID
- 14715499
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Grant note
- GM-07069 / NIGMS NIH HHS HL-57472 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS MH-65839 / NIMH NIH HHS
- Language
- English
- Date published
- 02/2004
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984065497902771
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