Journal article
Increases in pulse pressure impair acetylcholine-induced vascular relaxation
American journal of physiology. Heart and circulatory physiology, Vol.268(1), pp.H359-H363
01/01/1995
DOI: 10.1152/ajpheart.1995.268.1.H359
PMID: 7840284
Abstract
Effects of pulse pressure on acetylcholine-induced endothelium-dependent relaxation were investigated using a cascade bioassay model. Intact carotid arteries from rabbits were perfused at constant flow, and activity of endothelium-derived relaxing factor (EDRF) was assayed by measuring changes in isometric tension in a detector ring without endothelium. When pulse pressure of the donor artery was raised from approximately 2 to 10 mmHg, relaxation to acetylcholine (10(-7) M) was reduced from 31 +/- 3 (means +/- SE) to 20 +/- 2% (expressed as percent relaxation of phenylephrine-induced tone). Responses of the detector ring to nitroprusside were unchanged. Superoxide dismutase (SOD) and indomethacin each prevented impairment of relaxation to acetylcholine at high pulse pressure. When the donor artery was perfused at a higher mean pressure, elevation of pulse pressure also impaired relaxation to acetylcholine, and this impairment was prevented by SOD. These findings suggest that elevation of pulse pressure inhibits acetylcholine-induced, endothelium-dependent relaxation, and this inhibitory effect is mediated by generation of oxygen radicals.
Details
- Title: Subtitle
- Increases in pulse pressure impair acetylcholine-induced vascular relaxation
- Creators
- Stephen M Ryan - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242Barry J Waack - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242Barbara L Weno - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242Donald D Heistad - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.268(1), pp.H359-H363
- DOI
- 10.1152/ajpheart.1995.268.1.H359
- PMID
- 7840284
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 01/01/1995
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040495402771
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