Journal article
Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials
Stem cells international, Vol.2016(2016), pp.1-8
2016
DOI: 10.1155/2016/8657173
PMCID: PMC4972913
PMID: 27525011
Abstract
Background and Purpose. BM-MNCtransplantation improves recovery in experimentalmodels of ischemic stroke. Clinical trials are ongoing to test efficacy in stroke patients. However, whether cell dose is related to outcomes is not known. Methods. We performed a pooling data analysis of two pilot clinical trials with autologous BM-MNCs transplantation in ischemic stroke patients. Cell dose and route were analyzed to evaluate their relation to good outcome (m-Rankin scale [mRS] score 0-2) at 6 months. Results. Twenty-two patients were included. A median of 153 x 10(6) (+/- 121 x 10(6)) BM-MNCs was injected. Intra-arterial route was used in 77.3% of cases. A higher number of cells injected were associated with better outcomes at 180 days (390 x 10(6) [320-422] BM-MNCs injected in those patients with mRS of 0-2 at 6 months versus 130 x 10(6) [89-210] in those patients with mRS 3-6, p = 0.015). In the intraarterially treated patients, a strong correlation between dose of cells and disability was found (r = -0.63, p = 0.006). A cut point of 310 x 10(6) injected cells predicted good outcome with 80% sensitivity and 88.2% specificity. Conclusions. Similar to preclinical studies, a higher dose of autologous BM-MNC was related to better outcome in stroke patients, especially when more than 310 x 10(6) cells are injected. Further interventional studies are warranted to confirm these data.
Details
- Title: Subtitle
- Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials
- Creators
- Francisco Moniche - Hospital Universitario Virgen del RocíoPaulo Henrique Rosado-de-Castro - Universidade Federal do Rio de JaneiroIrene Escudero - Hosp Univ Virgen del Rocio, Dept Neurol, Seville 41013, SpainElena Zapata - Hosp Univ Virgen del Rocio, Dept Neurol, Seville 41013, SpainFrancisco Javier de la Torre Laviana - Hospital Universitario Virgen del RocíoRosalia Mendez-Otero - Universidade Federal do Rio de JaneiroMagdalena Carmona - Hospital Universitario Virgen del RocíoPilar Pinero - Hospital Universitario Virgen del RocíoAlejandro Bustamante - Vall d'Hebron Institut de RecercaLucia Lebrato - Hospital Universitario Virgen del RocíoJuan Antonio Cabezas - Hosp Univ Virgen del Rocio, Dept Neurol, Seville 41013, SpainAlejandro Gonzalez - Hospital Universitario Virgen del RocíoGrabriel R. de Freitas - D’Or Institute for Research and EducationJoan Montaner - Instituto de Biomedicina de Sevilla
- Resource Type
- Journal article
- Publication Details
- Stem cells international, Vol.2016(2016), pp.1-8
- DOI
- 10.1155/2016/8657173
- PMID
- 27525011
- PMCID
- PMC4972913
- NLM abbreviation
- Stem Cells Int
- ISSN
- 1687-966X
- eISSN
- 1687-9678
- Publisher
- Hindawi Publishing Group
- Number of pages
- 8
- Grant note
- Fundacion Mutua Madrilena; Instituto de Salud Carlos III TCRM 0001/2006 / Junta de Andalucia PI15/01197 / Instituto de Salud Carlos III; Spanish Government
- Language
- English
- Date published
- 2016
- Academic Unit
- Radiology
- Record Identifier
- 9985143123102771
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