Journal article
Incremental Redistribution of Protein Kinase C Underlies the Acquisition Curve During In Vitro Associative Conditioning in Hermissenda
Behavioral neuroscience, Vol.111(4), pp.739-753
08/1997
DOI: 10.1037/0735-7044.111.4.739
PMID: 9267651
Abstract
An incremental increase in the excitability (i.e., input
resistance, evoked spike frequency) of B photoreceptors in
Hermissenda
accompanied successive pairings of light
and presynaptic stimulation of vestibular hair cells (simulating
light-rotation pairings in an intact animal). Analysis of
protein kinase C (PKC) in the
Hermissenda
's
photoreceptors indicated a training-induced incremental reduction of
PKC in cytosolic compartments, a tendency toward an increase in
membrane compartments, and a small decrease in total enzyme activity
(possibly owing to a downregulation or conversion of PKC to a
calcium-independent state). Neither the biophysical or biochemical
effects were observed in
Hermissenda
exposed
to unpaired light and rotation or in those trained in the presence
of the selective PKC inhibitor NPC-15437 (which had no effect on
synaptic interactions or light-induced generator potentials). These
results suggest that the intracellular redistribution of a protein
kinase contributes critically to the kinetics of new learning.
Details
- Title: Subtitle
- Incremental Redistribution of Protein Kinase C Underlies the Acquisition Curve During In Vitro Associative Conditioning in Hermissenda
- Creators
- Isabel A Muzzio - Rutgers, The State University of New JerseyAndrew C Talk - Rutgers, The State University of New JerseyLouis D Matzel - Rutgers, The State University of New Jersey
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.111(4), pp.739-753
- DOI
- 10.1037/0735-7044.111.4.739
- PMID
- 9267651
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Publisher
- American Psychological Association
- Language
- English
- Date published
- 08/1997
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984295025402771
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