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Incremental Value of the Pancreas Allograft to the Survival of Simultaneous Pancreas-Kidney Transplant Recipients
Journal article   Open access   Peer reviewed

Incremental Value of the Pancreas Allograft to the Survival of Simultaneous Pancreas-Kidney Transplant Recipients

Paolo R. Salvalaggio, Nino Dzebisashvili, Brett Pinsky, Mark A. Schnitzler, Thomas E. Burroughs, Ralph Graff, David A. Axelrod, Daniel C. Brennan and Krista L. Lentine
Diabetes care, Vol.32(4), pp.600-602
04/01/2009
DOI: 10.2337/dc08-1718
PMCID: PMC2660461
PMID: 19131460
url
https://doi.org/10.2337/dc08-1718View
Published (Version of record) Open Access

Abstract

OBJECTIVE - To quantify the incremental survival benefit of the pancreas allograft in simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS - Data from the national transplant database from 2000 to 2007 were analyzed. SPK recipients who had functioning allografts to 1-year post transplant (n = 3,304) were compared with those who had failure of the renal (n = 233) or pancreatic (n = 112) graft. The main Outcome was a projection of 10 life-years of patient survival beyond the first transplant anniversary. RESULTS - Recipients with function of both organs accrued 9.4 life-years following transplantation. Projected survival in patients with kidney failure was reduced to 2.5 life-years. Pancreas failure reduced predicted survival to 8 life-years. Renal allograft failure impacts life expectancy significantly (adjusted hazard ratio [aHR] 12.13). However, pancreas allograft failure was also associated with reduced survival (aHR 2.62). CONCLUSIONS - Although the majority Of the survival benefit of SPK transplant is clue to the renal transplant, pancreas allograft function does contribute to patient survival.
 Endocrinology & Metabolism Life Sciences & Biomedicine Science & Technology

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