Journal article
Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives
Current topics in medicinal chemistry, Vol.22(14), pp.1177-1188
01/01/2022
DOI: 10.2174/1568026621666211214151534
PMCID: PMC10782885
PMID: 34906057
Abstract
Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.
Details
- Title: Subtitle
- Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives
- Creators
- Shravan Kumar Uppulapu - National Institute of Pharmaceutical Education and ResearchMd Jahangir Alam - Natl Inst Pharmaceut Educ & Res NIPER, Dept Biotechnol, Gauhati 781101, IndiaSantosh Kumar - University of IowaSanjay Kumar Banerjee - National Institute of Pharmaceutical Education and Research
- Resource Type
- Journal article
- Publication Details
- Current topics in medicinal chemistry, Vol.22(14), pp.1177-1188
- DOI
- 10.2174/1568026621666211214151534
- PMID
- 34906057
- PMCID
- PMC10782885
- NLM abbreviation
- Curr Top Med Chem
- ISSN
- 1568-0266
- eISSN
- 1873-4294
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 12
- Grant note
- 3/1/2(19)/OBS/2019-NCD-II / ICMR RA fellowship NIHR01HL152132 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BT/PR22881/BRB/10/1654/2018 / Department of Biotechnology
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984362295902771
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