Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila

Tamara Boto; Aaron Stahl; Xiaofan Zhang; Thierry Louis; Seth M. Tomchik

doi:10.1016/j.celrep.2019.04.069

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Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila

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Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila

Tamara Boto, Aaron Stahl, Xiaofan Zhang, Thierry Louis and Seth M. Tomchik

Cell reports (Cambridge), Vol.27(7), pp.2014-2021.e2

05/14/2019

DOI: 10.1016/j.celrep.2019.04.069

PMCID: PMC6585410

PMID: 31091441

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Abstract

Dopaminergic neurons play a key role in encoding associative memories, but little is known about how these circuits modulate memory strength. Here we report that different sets of dopaminergic neurons projecting to the Drosophila mushroom body (MB) differentially regulate valence and memory strength. PPL2 neurons increase odor-evoked calcium responses to a paired odor in the MB and enhance behavioral memory strength when activated during olfactory classical conditioning. When paired with odor alone, they increase MB responses to the paired odor but do not drive behavioral approach or avoidance, suggesting that they increase the salience of the odor without encoding strong valence. This contrasts with the role of dopaminergic PPL1 neurons, which drive behavioral reinforcement but do not alter odor-evoked calcium responses in the MB when stimulated. These data suggest that different sets of dopaminergic neurons modulate olfactory valence and memory strength via independent actions on a memory-encoding brain region. [Display omitted] •Two sets of dopaminergic neurons independently regulate memory encoding and strength•Dendrite-innervating PPL2 neurons regulate Ca2+ responses in memory-encoding neurons•PPL1 neurons drive aversive reinforcement (valence)•PPL2 neurons enhance memory strength without driving valence Boto et al. investigated the roles of two sets of dopaminergic neurons that converge on a memory-encoding brain region in flies. While one set, PPL1, drives aversive reinforcement (valence), PPL2 neurons enhance memory strength via modulation of Ca2+ response plasticity in memory-encoding mushroom body neurons.

dopamine

learning

plasticity

PPL1

PPL2

valence

Details

Title: Subtitle: Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila
Creators: Tamara Boto - Scripps Research Institute
Aaron Stahl - Scripps Research Institute
Xiaofan Zhang - Scripps Research Institute
Thierry Louis - Scripps Research Institute
Seth M. Tomchik - Scripps Research Institute
Resource Type: Journal article
Publication Details: Cell reports (Cambridge), Vol.27(7), pp.2014-2021.e2
DOI: 10.1016/j.celrep.2019.04.069
PMID: 31091441
PMCID: PMC6585410
NLM abbreviation: Cell Rep
ISSN: 2211-1247
eISSN: 2211-1247
Publisher: Elsevier Inc
Grant note: name: NIH/NIMH, award: R00 MH092294; name: NIH/NINDS, award: R01 NS097237; name: the Whitehall Foundation; name: Esther B. O’Keeffe Charitable Foundation
Language: English
Date published: 05/14/2019
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984303741602771

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