Journal article
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review
The American journal of dermatopathology, Vol.40(10), pp.736-748
10/2018
DOI: 10.1097/DAD.0000000000001191
PMID: 29877893
Abstract
Indeterminate dendritic cell tumor (IDCT) is a cutaneous proliferation of histiocytes that share morphologic and immunophenotypic properties with Langerhans cells. IDCT was recently included in the updated WHO classification of tumors of hematopoietic and lymphoid tissues. Recent studies have shown that some cases of IDCT demonstrate an ETV3-NCOA2 translocation, supporting the idea that IDCT is a clonal neoplasm. We report 2 new cases of IDCT at our institution lacking the ETV3-NCOA2 translocation. We also present a comprehensive review of reported cases of IDCT in the medical literature. Eighty-five cases of IDCT were reported in the literature between 1985 and 2016. The median age at diagnosis was 45 years. In contrast to Langerhans cell histiocytosis, IDCT is limited to the skin in the majority of cases (88%) and generally follows an indolent clinical course. Most reported lesions are cured with complete excision. However, the histologic features of IDCT and langerhans cell histiocytosis are similar. Conjoint immunostaining for CD1a and langerin is necessary for optimal classification.
Details
- Title: Subtitle
- Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review
- Creators
- Jonathan J Davick - University of VirginiaJinah Kim - Stanford UniversityMark R Wick - University of VirginiaAlejandro A Gru - University of Virginia
- Resource Type
- Journal article
- Publication Details
- The American journal of dermatopathology, Vol.40(10), pp.736-748
- DOI
- 10.1097/DAD.0000000000001191
- PMID
- 29877893
- ISSN
- 0193-1091
- eISSN
- 1533-0311
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Pathology
- Record Identifier
- 9984186678002771
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