Journal article
Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER
Genetics (Austin), Vol.100(4), pp.597-614
04/1982
PMCID: PMC1201835
PMID: 17246073
Abstract
Two classes of
X
-linked behavioral mutants of
Drosophila melanogaster
, leg-shaking mutants and bang-sensitive mutants, are suppressed by
nap
ts
(no action potential, temperature-sensitive), an autosomal temperature-sensitive paralytic mutation. So far,
nap
ts
is found to suppress thirteen mutations at seven loci, two of which produce leg shaking and five bang-sensitivity. Suppression is recessive, occurs at temperatures permissive for
nap
ts
, and is indirect and function-specific rather than allele-specific. At restrictive temperatures,
nap
ts
is known to completely block all nerve activity. Several of the mutants suppressed by
nap
ts
are shown by neurophysiological experiments to have increased nerve excitability. The physiological defect of these mutants as well as their behavioral defect is suppressed by
nap
ts
. Thus, suppression occurs within individual neurons at the level of excitable membranes and apparently depends on the reduction in membrane excitability caused by
nap
ts
even under permissive conditions. We suggest that all mutants suppressed by
nap
ts
may have related defects leading to enhanced nerve excitability. Genetic interactions of this type help reveal functional relationships between different behavioral mutants and suggest ways of isolating new mutants with altered excitable membranes.
Details
- Title: Subtitle
- Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER
- Creators
- Barry GanetzkyChun-Fang Wu
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.100(4), pp.597-614
- PMID
- 17246073
- PMCID
- PMC1201835
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Language
- English
- Date published
- 04/1982
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984071783102771
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