Journal article
Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: The higher they start, the harder they fall
Pediatric diabetes, Vol.20(1), pp.99-106
02/2019
DOI: 10.1111/pedi.12799
PMID: 30467929
Abstract
Objective
To evaluate the pattern of change in blood glucose concentrations and hypoglycemia risk in response to prolonged aerobic exercise in adolescents with type 1 diabetes (T1D) that had a wide range in pre‐exercise blood glucose concentrations.
Methods
Individual blood glucose responses to prolonged (~60 minutes) moderate‐intensity exercise were profiled in 120 youth with T1D.
Results
The mean pre‐exercise blood glucose concentration was 178 ± 66 mg/dL, ranging from 69 to 396 mg/dL, while the mean change in glucose during exercise was −76 ± 55 mg/dL (mean ± SD), ranging from +83 to −257 mg/dL. Only 4 of 120 youth (3%) had stable glucose levels during exercise (ie, ± ≤10 mg/dL), while 4 (3%) had a rise in glucose >10 mg/dL, and the remaining (93%) had a clinically significant drop (ie, >10 mg/dL). A total of 53 youth (44%) developed hypoglycemia (≤70 mg/dL) during exercise. The change in glucose was negatively correlated with the pre‐exercise glucose concentration (R2 = 0.44, P < 0.001), and tended to be greater in those on multiple daily insulin injections (MDI) vs continuous subcutaneous insulin infusion (CSII) (−98 ± 15 vs −65 ± 7 mg/dL, P = 0.05). No other collected variables appeared to predict the change in glucose including age, weight, height, body mass index, disease duration, daily insulin dose, HbA1c, or sex.
Conclusion
Youth with T1D have variable glycemic responses to prolonged aerobic exercise, but this variability is partially explained by their pre‐exercise blood glucose levels. When no implementation strategies are in place to limit the drop in glycemia, the incidence of exercise‐associated hypoglycemia is ~44% and having a high pre‐exercise blood glucose concentration is only marginally protective.
Details
- Title: Subtitle
- Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: The higher they start, the harder they fall
- Creators
- Michael C Riddell - LMC Diabetes and EndocrinologyDessi P Zaharieva - Muscle Health Research CentreMichael Tansey - Pediatric Endocrinology, University of IowaEva Tsalikian - Pediatric Endocrinology, University of IowaGil Admon - Clalit Health ServicesZoey Li - Jaeb Center for Health ResearchCraig Kollman - Jaeb Center for Health ResearchRoy W Beck - Jaeb Center for Health Research
- Resource Type
- Journal article
- Publication Details
- Pediatric diabetes, Vol.20(1), pp.99-106
- DOI
- 10.1111/pedi.12799
- PMID
- 30467929
- NLM abbreviation
- Pediatr Diabetes
- ISSN
- 1399-543X
- eISSN
- 1399-5448
- Publisher
- John Wiley & Sons A/S
- Number of pages
- 8
- Language
- English
- Date published
- 02/2019
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093479002771
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