Indolent CD8+ lymphoid proliferation of the ear: report of two cases and review of the literature

Brian L Swick; Christian L Baum; Arun P Venkat; Vincent Liu

doi:10.1111/j.1600-0560.2010.01647.x

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Indolent CD8+ lymphoid proliferation of the ear: report of two cases and review of the literature

Journal article

Peer reviewed

Indolent CD8+ lymphoid proliferation of the ear: report of two cases and review of the literature

Brian L Swick, Christian L Baum, Arun P Venkat and Vincent Liu

Journal of cutaneous pathology, Vol.38(2), pp.209-215

02/2011

DOI: 10.1111/j.1600-0560.2010.01647.x

PMID: 21083681

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Abstract

Indolent CD8+ lymphoid proliferation of the ear is a recently described cutaneous lymphoid proliferation that clinically presents with slow growing lesion(s) on the ear(s). In cases reported to date, there has been indolent clinical behavior and no evidence of systemic involvement. Characteristic histopathologic features include a non-epidermotropic diffuse dermal infiltrate of CD8+ T-lymphocytes with a lymphoblast-like appearance. T-cell clonality has also been observed. Herein, we present two patients who show clinical, histopathologic and immunophenotypic features similar to the original index cases described by Petrella et al. In addition, we review the literature regarding this unusual lymphoid proliferation and provide evidence that this entity represents a phenotypic variant of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma, a concept proposed by Beltraminelli et al. in 2009. Differentiation between this lymphoproliferative process and other more aggressive CD8+ lymphomas is essential in avoiding excessive treatment of a condition that combines worrisome histopathology with indolent clinical behavior.

Lymphoma, T-Cell, Cutaneous - pathology

Skin Neoplasms - pathology

CD8-Positive T-Lymphocytes - pathology

Cell Proliferation

Humans

Middle Aged

Adult

Male

Ear - pathology

Details

Title: Subtitle: Indolent CD8+ lymphoid proliferation of the ear: report of two cases and review of the literature
Creators: Brian L Swick - Departments of Dermatology and Pathology, University of Iowa, Iowa City, IA 52242, USA. swickbrian@yahoo.com
Christian L Baum
Arun P Venkat
Vincent Liu
Resource Type: Journal article
Publication Details: Journal of cutaneous pathology, Vol.38(2), pp.209-215
Publisher: United States
DOI: 10.1111/j.1600-0560.2010.01647.x
PMID: 21083681
ISSN: 0303-6987
eISSN: 1600-0560
Language: English
Date published: 02/2011
Academic Unit: Dermatology; Pathology
Record Identifier: 9984025350802771

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