Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids

Donald D Malcolm; Jeffrey L Segar; Jean E Robillard; Sylvain Chemtob

doi:10.1152/jappl.1993.74.4.1672

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Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids

Journal article

Peer reviewed

Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids

Donald D Malcolm, Jeffrey L Segar, Jean E Robillard and Sylvain Chemtob

Journal of applied physiology (1985), Vol.74(4), pp.1672-1678

04/01/1993

DOI: 10.1152/jappl.1993.74.4.1672

PMID: 8514682

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Abstract

We examined whether prostanoids contribute to the impaired cardiac function and decrease in regional blood flow induced by increasing mean airway pressure. Using microspheres, we measured cardiac output and major organ blood flow and assayed prostaglandin E2, 6-ketoprostaglandin F1 alpha, and thromboxane B2 in blood at mean airway pressures of 5-25 cmH2O in mechanically ventilated newborn piglets treated with ibuprofen (40 mg/kg, n = 6), indomethacin (0.3 mg/kg, n = 6), or vehicle (n = 6). Blood gases and pH were stable throughout the experiments. Prostanoid levels remained constant with increasing mean airway pressure in vehicle-treated pigs and were unchanged by indomethacin. However, ibuprofen decreased the prostanoid levels at all mean airway pressures studied (P < 0.01). As ventilatory pressure was progressively increased, cardiac output decreased gradually and similarly by 42-45% (P < 0.05) in all groups. At the highest mean airway pressure, blood flow decreased to the kidneys by 37-57%, to the ileum by 58-74%, and to the colon by 53-71% (P < 0.05) in all groups. Cerebral blood flow remained constant at all ventilatory pressures regardless of the treatment. There was no difference in cardiac output and regional hemodynamics between ibuprofen- and vehicle-treated animals. However, after indomethacin, ileal blood flow at the higher ventilatory pressures was 41-46% lower and cerebral blood flow at all mean airway pressures was 14-25% lower than after the other treatments (P < 0.05).

Animals

Animals, Newborn

Blood Pressure - drug effects

Blood Pressure - physiology

Cardiac Output - drug effects

Cardiac Output - physiology

Heart Rate - drug effects

Heart Rate - physiology

Hemodynamics - drug effects

Hemodynamics - physiology

Ibuprofen - pharmacology

Indomethacin - pharmacology

Positive-Pressure Respiration - adverse effects

Prostaglandins - blood

Prostaglandins - physiology

Regional Blood Flow - drug effects

Regional Blood Flow - physiology

Respiratory Mechanics - physiology

Swine

Details

Title: Subtitle: Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids
Creators: Donald D Malcolm - University of Iowa
Jeffrey L Segar - University of Iowa
Jean E Robillard - University of Iowa
Sylvain Chemtob - University of Iowa
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.74(4), pp.1672-1678
DOI: 10.1152/jappl.1993.74.4.1672
PMID: 8514682
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Language: English
Date published: 04/01/1993
Academic Unit: Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
Record Identifier: 9984774213602771

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