Induced Opening of the Gastroesophageal Junction Occurs at a Lower Gastric Pressure in Gerd Patients and in Hiatal Hernia Subjects than in Normal Control Subjects

Anil Vegesna; Ramashesai Besetty; Amit Kalra; Umar Farooq; Annapurna Korimilli; Keng yu Chuang; Robert Fisher; Henry Parkman; Larry Miller

doi:10.1155/2010/857654

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Induced Opening of the Gastroesophageal Junction Occurs at a Lower Gastric Pressure in Gerd Patients and in Hiatal Hernia Subjects than in Normal Control Subjects

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Induced Opening of the Gastroesophageal Junction Occurs at a Lower Gastric Pressure in Gerd Patients and in Hiatal Hernia Subjects than in Normal Control Subjects

Anil Vegesna, Ramashesai Besetty, Amit Kalra, Umar Farooq, Annapurna Korimilli, Keng yu Chuang, Robert Fisher, Henry Parkman and Larry Miller

Gastroenterology research and practice, Vol.2010, pp.1-5

2010

DOI: 10.1155/2010/857654

PMCID: PMC2842887

PMID: 20339562

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Abstract

Purpose. To determine intragastric pressure threshold for inducing gastroesophageal junction (GEJ) opening in normal control subjects with and without hiatal hernia, and in patients with gastroesophageal reflux disease.Methods. This study was performed in 13 normal volunteers, 5 volunteers with hiatal hernia, and 3 patients with gastroesophageal reflux disease. During endoscopy a pressure transducer was used to measure baseline gastric pressures. The pressure in the stomach was measured while air was insufflated into the stomach until the gastroesophageal junction opened on endoscopic view.Results. There were two patterns of GEJ opening in normal volunteers. The mean opening pressure for Gastroesophageal junction in normal pattern-I, normal pattern-II, hiatal hernia, and Gastroesophageal reflux patients was 11.5, 12.6, 3.4, and 1.3 mmHg, respectively.Conclusions. GEJ opening is induced at a significantly lower pressure in subjects with hiatal hernia and in patients with gastroesophageal reflux disease than in normal volunteers.

Details

Title: Subtitle: Induced Opening of the Gastroesophageal Junction Occurs at a Lower Gastric Pressure in Gerd Patients and in Hiatal Hernia Subjects than in Normal Control Subjects
Creators: Anil Vegesna - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Ramashesai Besetty - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Amit Kalra - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Umar Farooq - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Annapurna Korimilli - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Keng yu Chuang - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Robert Fisher - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Henry Parkman - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Larry Miller - Section of Gastroenterology, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
Resource Type: Journal article
Publication Details: Gastroenterology research and practice, Vol.2010, pp.1-5
DOI: 10.1155/2010/857654
PMID: 20339562
PMCID: PMC2842887
NLM abbreviation: Gastroenterol Res Pract
ISSN: 1687-6121
eISSN: 1687-630X
Language: English
Date published: 2010
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094566202771

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