Journal article
Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics
British journal of pharmacology, Vol.177(20), pp.4581-4594
10/2020
DOI: 10.1111/bph.15228
PMCID: PMC7520445
PMID: 32767563
Abstract
Recent advances in human induced pluripotent stem cell (iPSC) technology may provide unprecedented opportunities to study patient-specific responses to anaesthetics and opioids. In this review, we will (1) examine the advantages and limitations of iPSC technology, (2) summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular system and central nervous system (CNS), and (3) describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies with reduced or minimal detrimental cardiovascular effects.
Details
- Title: Subtitle
- Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics
- Creators
- Detlef Obal - Stanford UniversityJoseph C. Wu - Stanford University
- Resource Type
- Journal article
- Publication Details
- British journal of pharmacology, Vol.177(20), pp.4581-4594
- DOI
- 10.1111/bph.15228
- PMID
- 32767563
- PMCID
- PMC7520445
- NLM abbreviation
- Br J Pharmacol
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- IRSA 1015009 / Burroughs Wellcome Foundation; Burroughs Wellcome Fund Stanford Cardiovascular Institute Seed grant 27IR-0012 / Tobaccorelated Disease Research Program (TRDRP) R01 HL141371; R01 HL146690; UH3 TR002588 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Transdisciplinary Initiatives Program (TIP) Award, Stanford Maternal & Child Health Research Institute
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Anesthesia
- Record Identifier
- 9984696713402771
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