Journal article
Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy
Frontiers in immunology, Vol.12, pp.675538-675538
05/14/2021
DOI: 10.3389/fimmu.2021.675538
PMCID: PMC8160316
PMID: 34054863
Abstract
Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response. Sharing structural and functional characteristics with conventional secondary lymphoid organs (SLO) including discrete T cell zones, B cell zones, marginal zones with antigen presenting cells, reticular stromal networks, and high endothelial venues (HEV), TLS are prominent centers of antigen presentation and adaptive immune activation within the periphery. TLS share many signaling axes and leukocyte recruitment schemes with SLO regarding their formation and function. In cancer, their presence confers positive prognostic value across a wide spectrum of indications, spurring interest in their artificial induction as either a new form of immunotherapy, or as a means to augment other cell or immunotherapies. Here, we review approaches for inducible (iTLS) that utilize chemokines, inflammatory factors, or cellular analogues vital to TLS formation and that often mirror conventional SLO organogenesis. This review also addresses biomaterials that have been or might be suitable for iTLS, and discusses remaining challenges facing iTLS manufacturing approaches for clinical translation.
Details
- Title: Subtitle
- Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy
- Creators
- Shota Aoyama - Tokyo Women's Medical UniversityRyosuke Nakagawa - Tokyo Women's Medical UniversityJames J. Mule - Moffitt Cancer CenterAdam W. Mailloux - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in immunology, Vol.12, pp.675538-675538
- DOI
- 10.3389/fimmu.2021.675538
- PMID
- 34054863
- PMCID
- PMC8160316
- NLM abbreviation
- Front Immunol
- ISSN
- 1664-3224
- eISSN
- 1664-3224
- Publisher
- Frontiers Media Sa
- Number of pages
- 13
- Grant note
- V Foundation Dr. Miriam and Sheldon G. Adelson Medical Research Foundation Cindy and Jon Gruden Fund 1R01 CA148995; 1R01 CA184845; P30 CA076292; P50 CA168536; 5R21CA214285 / NCI-NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Chris Sullivan Fund
- Language
- English
- Date published
- 05/14/2021
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297329602771
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