Journal article
Induction of LTD-like corticospinal plasticity by low-frequency rTMS depends on pre-stimulus phase of sensorimotor mu-rhythm
Brain stimulation, Vol.13(6), pp.1580-1587
11/01/2020
DOI: 10.1016/j.brs.2020.09.005
PMCID: PMC7710977
PMID: 32949780
Abstract
Background: Neural oscillations reflect rapidly changing brain excitability states. We have demonstrated previously with EEG-triggered transcranial magnetic stimulation (TMS) of human motor cortex that the positive vs. negative peak of the sensorimotor tt-oscillation reflect corticospinal low-vs. high-excitability states. In vitro experiments showed that induction of long-term depression (LTD) by low-frequency stimulation depends on the postsynaptic excitability state.
Objective/Hypothesis: We tested the hypothesis that induction of LTD-like corticospinal plasticity in humans by 1 Hz repetitive TMS (rTMS) is enhanced when rTMS is synchronized with the low-excitability state, but decreased or even shifted towards long-term (LTP)-like plasticity when synchronized with the high-excitability state.
Methods: We applied real-time EEG-triggered 1-Hz-rTMS (900 pulses) to the hand area of motor cortex in healthy subjects. In a randomized double-blind three-condition crossover design, pulses were synchronized to either the positive or negative peak of the sensorimotor mu-oscillation, or were applied at random phase (control). The amplitude of motor evoked potentials was recorded as an index of corticospinal excitability before and after 1-Hz-rTMS.
Results: 1-Hz-rTMS at random phase resulted in a trend towards LTD-like corticospinal plasticity. RTMS in the positive peak condition (i.e., the low-excitability state) induced significant LTD-like plasticity. RTMS in the negative peak condition (i.e., the high-excitability state) showed a trend towards LTP-like plasticity, which was significantly different from the other two conditions.
Conclusion: The level of corticospinal depolarization reflected by phase of the mu-oscillation determines the degree of corticospinal plasticity induced by low-frequency rTMS, a finding that may guide future personalized therapeutic stimulation. (C) 2020 The Author(s). Published by Elsevier Inc.
Details
- Title: Subtitle
- Induction of LTD-like corticospinal plasticity by low-frequency rTMS depends on pre-stimulus phase of sensorimotor mu-rhythm
- Creators
- David Baur - University of TübingenDragana Galevska - University of TübingenSara Hussain - National Institute of Neurological Disorders and StrokeLeonardo G. Cohen - National Institutes of HealthUlf Ziemann - Hertie Institute for Clinical Brain ResearchChristoph Zrenner - Hertie Institute for Clinical Brain Research
- Resource Type
- Journal article
- Publication Details
- Brain stimulation, Vol.13(6), pp.1580-1587
- DOI
- 10.1016/j.brs.2020.09.005
- PMID
- 32949780
- PMCID
- PMC7710977
- NLM abbreviation
- Brain Stimul
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- 810377 / European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme; European Research Council (ERC) 437-0-0 / Junior Clinician Scientist Program of the Faculty of Medicine, University of Tubingen ZI 542/7-1 / German Research Foundation; German Research Foundation (DFG) 391-0-0 / Clinician Scientist Program of the Faculty of Medicine, University of Tubingen NINDS Intramural Competitive Fellowship Program
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984948041502771
Metrics
1 Record Views