Journal article
Induction of Neuronal Vascular Endothelial Growth Factor Expression by cAMP in the Dentate Gyrus of the Hippocampus Is Required for Antidepressant-Like Behaviors
The Journal of neuroscience, Vol.29(26), pp.8493-8505
07/01/2009
DOI: 10.1523/JNEUROSCI.1321-09.2009
PMCID: PMC2796224
PMID: 19571140
Abstract
The cAMP cascade and vascular endothelial growth factor (VEGF) are critical modulators of depression. Here we have tested whether the antidepressive effect of the cAMP cascade is mediated by VEGF in the adult hippocampus. We used a conditional genetic system in which the
Aplysia
octopamine receptor (Ap oa
1
), a G
s
-coupled receptor, is transgenically expressed in the forebrain neurons of mice. Chronic activation of the heterologous Ap oa
1
by its natural ligand evoked antidepressant-like behaviors, accompanied by enhanced phosphorylation of cAMP response element-binding protein and transcription of VEGF in hippocampal dentate gyrus (DG) neurons. Selective knockdown of VEGF in these cells during the period of cAMP elevation inhibited the antidepressant-like behaviors. These findings reveal a molecular interaction between the cAMP cascade and VEGF expression, and the pronounced behavioral consequences of this interaction shed light on the mechanism underlying neuronal VEGF functions in antidepression.
Details
- Title: Subtitle
- Induction of Neuronal Vascular Endothelial Growth Factor Expression by cAMP in the Dentate Gyrus of the Hippocampus Is Required for Antidepressant-Like Behaviors
- Creators
- Jeong-Sik Lee - Departments ofDeok-Jin Jang - School of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, KoreaNuribalhae Lee - School of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, KoreaHyoung-Gon Ko - School of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, KoreaHyoung Kim - School of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, KoreaYong-Seok Kim - Departments ofByungwoo Kim - Departments ofJunehee Son - School of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, KoreaSung Hyun Kim - Departments ofHeekyoung Chung - Pathology, Hanyang University College of Medicine, 133-791 Seoul, KoreaMun-Yong Lee - Department of Anatomy, College of Medicine, The Catholic University of Korea, 137-701 Seoul, KoreaWoon Ryoung Kim - Department of Anatomy, Korea University College of Medicine, 136-701 Seoul, KoreaWoong Sun - Department of Anatomy, Korea University College of Medicine, 136-701 Seoul, KoreaMin Zhuo - Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada, andTed Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104Bong-Kiun Kaang - School of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, KoreaHyeon Son - Departments of
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.29(26), pp.8493-8505
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.1321-09.2009
- PMID
- 19571140
- PMCID
- PMC2796224
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 07/01/2009
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065731902771
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