Journal article
Induction of both cytochromes P-450 and P-448 by 2,3′,4,4′,5-pentabromobiphenyl, a component of fireMaster
Biochemical and biophysical research communications, Vol.92(1), pp.175-182
1980
DOI: 10.1016/0006-291X(80)91536-3
PMID: 6243934
Abstract
The synthesis and purification of a component of fireMaster BP-6 and fireMaster FF-1, 2,3′,4,4′,5-pentabromobiphenyl, is described. The compound was found to be a potent inducer of liver microsomal drug-metabolizing enzymes in the rat, enhancing those enzymic activities induced by both phenobarbitone and 3-methylcholanthrene (i.e. cytochromes P-450 and P-448). The pentabromobiphenyl enhanced the activities of benzo[a]pyrene hydroxylase, dimethylamino-antipyrine N-demethylase and NADPH-cytochrome c reductase. The hepatic cytochromes b
5 and P-450 were increased and the Soret peak maximum of the latter was shifted to 448.5 nm. The relative peak intensities and spectral shifts for the ethylisocyanide-binding difference spectra confirmed the mixed induction characteristics of 2,3′,4,4′,5-pentabromobiphenyl.
Details
- Title: Subtitle
- Induction of both cytochromes P-450 and P-448 by 2,3′,4,4′,5-pentabromobiphenyl, a component of fireMaster
- Creators
- L.W. Robertson - University of MichiganA. Parkinson - University of GuelphS. Safe - University of Guelph
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.92(1), pp.175-182
- DOI
- 10.1016/0006-291X(80)91536-3
- PMID
- 6243934
- NLM abbreviation
- Biochem Biophys Res Commun
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1980
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984364456502771
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