Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats

Larissa Resende Oliveira; Vitor Ulisses de Melo; Fabricio Nunes Macedo; Andre Sales Barreto; Daniel Badaue-Passos; Marcio Roberto Viana dos Santos; Daniel Penteado Martins Dias; Kathleen A Sluka; Josimari M DeSantana; Valter J Santana-Filho

doi:10.1016/j.autneu.2011.12.004

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Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats

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Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats

Larissa Resende Oliveira, Vitor Ulisses de Melo, Fabricio Nunes Macedo, Andre Sales Barreto, Daniel Badaue-Passos, Marcio Roberto Viana dos Santos, Daniel Penteado Martins Dias, Kathleen A Sluka, Josimari M DeSantana and Valter J Santana-Filho

Autonomic neuroscience, Vol.167(1-2), pp.45-49

04/03/2012

DOI: 10.1016/j.autneu.2011.12.004

PMCID: PMC4667978

PMID: 22266357

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Abstract

Fibromyalgia (FM) is characterized by chronic non-inflammatory widespread pain (CWP) and changes in sympathetic function. In attempt to elucidate the pathophysiological mechanisms of FM we used a well-established CWP animal model. We aimed to evaluate changes in cardiac autonomic balance and baroreflex function in response to CWP induction in rats. CWP was induced by two injections of acidic saline (pH 4.0, n=8) five days apart into the left gastrocnemius muscle. Control animals were injected twice with normal saline (pH 7.2, n=6). One day after the second injection of acidic saline or normal saline, the animals had pulse interval (PI) and systolic arterial pressure (SAP) variability, and spontaneous baroreflex sensitivity (BRS) evaluated. After induction of CWP, there was an increase of power in the low frequency (LF) band of PI spectrum (12.75±1.04nu), a decrease in the high frequency (HF) band (87.25±1.04nu) and an increase of LF/HF ratio (0.16±0.01), when compared to control animals (7.83±1.13nu LF; 92.16±1.13nu HF; 0.08±0.01 LF/HF). In addition, there was an increase of power in the LF band of SAP spectrum (7.93±1.39mmHg2) when compared to control animals (2.97±0.61mmHg2). BRS was lower in acidic saline injected rats (0.59±0.06ms/mmHg) when compared to control animals (0.71±0.03ms/mmHg). Our results showed that induction of CWP in rats shifts cardiac sympathovagal balance towards sympathetic predominance and decreases BRS. These data corroborate findings in humans with FM.

Fibromyalgia

Chronic muscle pain

Cardiovascular variability

Blood pressure

Baroreflex

Sequence method

Details

Title: Subtitle: Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats
Creators: Larissa Resende Oliveira - Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
Vitor Ulisses de Melo - Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
Fabricio Nunes Macedo - Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
Andre Sales Barreto - Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
Daniel Badaue-Passos - Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
Marcio Roberto Viana dos Santos - Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
Daniel Penteado Martins Dias - Department of Physiology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Kathleen A Sluka - Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, United States
Josimari M DeSantana - Department of Physical Therapy, Federal University of Sergipe, Aracaju, Brazil
Valter J Santana-Filho - Department of Physical Therapy, Federal University of Sergipe, Aracaju, Brazil
Resource Type: Journal article
Publication Details: Autonomic neuroscience, Vol.167(1-2), pp.45-49
DOI: 10.1016/j.autneu.2011.12.004
PMID: 22266357
PMCID: PMC4667978
NLM abbreviation: Auton Neurosci
ISSN: 1566-0702
eISSN: 1872-7484
Publisher: Elsevier B.V
Language: English
Date published: 04/03/2012
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984040225902771

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