Journal article
Induction of chronic non‐inflammatory widespread pain in rats increases sympathetic activity
The FASEB journal, Vol.25, pp.lb604-lb604
04/2011
DOI: 10.1096/fasebj.25.1_supplement.lb604
Abstract
Fibromyalgia (FM) is characterized by chronic non‐inflammatory widespread pain (CWP). Changes in sympathetic function occur in patients with FM. In attempt to elucidate the pathophysiology mechanisms of FM we used an animal model that mimics FM symptoms. We aimed to evaluate changes in the autonomic balance as well as baroreflex function in response to CWP induction in rats. 14 wistar male rats with (GSA, n=8) and without (GSN, n=6) the induction of CWP were used. CWP was induced by two injections of pH 4.0 saline into the gastrocnemius muscle. 24 hours after the second injection of acid or neutral saline the animals were instrumentated to record blood pressure (BP), analyze variability of pulse interval (IP) and BP, and analyze spontaneous barorefex sensibility (BRS). After induction of CWP, there was an increase in the oscillations (IP variability) at LF (11 ± 1.18), a decrease in the oscillations at HF (89 ± 1.18) which results in an increase in the LF/HF ratio (0.14 ± 0.02) when compared to controls (7 ± 0.4 LF; 93 ± 0.4 HF; 0.08 ± 0.00 LF/HF;). There was no difference in BP oscillations in LF between groups (50 ± 3.9% GSA vs 38 ± 5.5% GSN, p= 0.09). BRS was reduced when compared to controls (11,87 ± 1,42 mmHg/s GSA vs 17,45 ± 3,10 mmHg/s GSN, p= 0.04) Our results showed that induction of CWP in rats shifts the autonomic balance towards sympathetic tone as well as decrease the BRS, conditions that are also seen in humans with FM.
Details
- Title: Subtitle
- Induction of chronic non‐inflammatory widespread pain in rats increases sympathetic activity
- Creators
- Vitor Ulisses Melo - Federal University of SergipeLarissa Resende Oliveira - Federal University of SergipeFabricio Nunes Macedo - Federal University of SergipeAndre Sales Barreto - Federal University of SergipeDaniel Badaue Passos - Federal University of SergipeMarcio Roberto Viana Santos - Federal University of SergipeKathleen A Sluka - University of IowaJosimari M DeSantana - Federal University of SergipeValter J Santana‐Filho - Federal University of Sergipe
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.25, pp.lb604-lb604
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.lb604
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984071951802771
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