Induction of maturation of human B-cell lymphomas in vitro. Morphologic changes in relation to immunoglobulin and DNA synthesis

K Beiske; E Ruud; A Drack; P F Marton; T Godal

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Induction of maturation of human B-cell lymphomas in vitro. Morphologic changes in relation to immunoglobulin and DNA synthesis

Journal article

Peer reviewed

Induction of maturation of human B-cell lymphomas in vitro. Morphologic changes in relation to immunoglobulin and DNA synthesis

K Beiske, E Ruud, A Drack, P F Marton and T Godal

The American journal of pathology, Vol.115(3), pp.362-374

06/1984

PMCID: PMC1900525

PMID: 6375389

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Abstract

In vitro stimulation of cells from 8 non-Hodgkin's lymphomas comprising several histologic types with a tumor promotor (TPA) and with or without anti-immunoglobulins directed against the surface immunoglobulin of the tumor cells is reported. Morphologic transformation to immunoblastic and plasmablastic cells, but not to plasma cells, and induction of Ig and DNA synthesis were observed. A comparative analysis, including flow cytofluorometry, light microscopy combined with immunocytochemistry, and electron microscopy, suggests that the three events may not always be associated phenomena at the single-cell level even in monoclonal cell populations.

Lymphoma - ultrastructure

Humans

Cells, Cultured

Lymphoma - immunology

Microscopy, Electron

Cell Transformation, Neoplastic - ultrastructure

Immunoenzyme Techniques

Lymphoma - metabolism

Cell Transformation, Neoplastic - immunology

B-Lymphocytes - immunology

Carcinogens - pharmacology

DNA, Neoplasm - biosynthesis

Flow Cytometry

Histocytochemistry

Cell Transformation, Neoplastic - drug effects

Immunoglobulins - biosynthesis

B-Lymphocytes - metabolism

B-Lymphocytes - ultrastructure

Suspensions

Details

Title: Subtitle: Induction of maturation of human B-cell lymphomas in vitro. Morphologic changes in relation to immunoglobulin and DNA synthesis
Creators: K Beiske
E Ruud
A Drack
P F Marton
T Godal
Resource Type: Journal article
Publication Details: The American journal of pathology, Vol.115(3), pp.362-374
Publisher: United States
PMID: 6375389
PMCID: PMC1900525
ISSN: 0002-9440
eISSN: 1525-2191
Language: English
Date published: 06/1984
Academic Unit: Stead Family Department of Pediatrics; Ophthalmology and Visual Sciences
Record Identifier: 9983979990202771

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11 Times Cited - Web of Science