Journal article
Infant Renal Replacement Therapy Using Carpediem™: A Multicenter Observational Cohort Study from the ICONIIC Learning Network
The Journal of pediatrics, Vol.288, 114838
01/2026
DOI: 10.1016/j.jpeds.2025.114838
PMID: 41016463
Abstract
To evaluate indications and outcomes of Carpediem™ as the first infant-specific continuous renal replacement therapy (CRRT) platform available for clinical use in the US.
A multicenter, retrospective and prospective observational study was conducted through the "Improving CRRT Outcomes in Neonates and Infants through Interdisciplinary Collaboration (ICONIIC)" Learning Network. Data were collected from the first four US centers utilizing Carpediem™. A treatment course was defined as sequential CRRT procedures separated by ≤72 hours. Infant cohorts were categorized by CRRT indication: end-stage kidney disease (ESKD) (ie, CRRT as a bridge to PD) and non-ESKD (all other indications).
Sixty-seven infants underwent 93 treatment courses using 1,538 filters and 112 vascular access catheters. Primary indication for CRRT was ESKD in 36 (54%) and acute kidney injury in 43%. Median age at first treatment was 18 (IQR: 6, 81) days, and dry weight 2.6 (IQR: 2.4, 3.1) kg for the ESKD cohort and 32 (IQR: 9, 90) days and 3.4 (IQR: 3.2, 4.5])kg for the non-ESKD cohort. Median treatment course duration was 12 (IQR: 3,24) days for ESKD compared with 4 [IQR: 1,13] days for non-ESKD infants. Survival to hospital discharge was 67% in ESKD and 60% in non-ESKD.
In this US cohort study, CRRT survival in infants treated with Carpediem™ exceeds 60%. More than half of the treatment indications were for ESKD as a bridge to dialysis.
Details
- Title: Subtitle
- Infant Renal Replacement Therapy Using Carpediem™: A Multicenter Observational Cohort Study from the ICONIIC Learning Network
- Creators
- Cara L Slagle - Cincinnati Children's Hospital Medical CenterKim T Vuong - Texas Children's HospitalKelli A Krallman - Cincinnati Children's Hospital Medical CenterLauren Casey - Texas Children's HospitalKatja M Gist - University of Colorado Anschutz Medical CampusJennifer G Jetton - Medical College of WisconsinCatherine Joseph - Texas Children's HospitalKera Luckritz - C. S. Mott Children's HospitalSusan D Martin - Golisano Children's HospitalJolyn Morgan - Cincinnati Children's Hospital Medical CenterKyle A Merrill - University of IowaKatie Plomaritas - C. S. Mott Children's HospitalDavid Ramirez - Mayo ClinicCheryl L Tran - Mayo Clinic in ArizonaH Stella Shin - Emory University School of MedicineAmanda N Snyder - Cincinnati Children's Hospital Medical CenterBrynna Van Wyk - University of IowaLarissa Yalon - Seattle Children's HospitalStuart L Goldstein - Cincinnati Children's Hospital Medical CenterShina Menon - Stanford University
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.288, 114838
- DOI
- 10.1016/j.jpeds.2025.114838
- PMID
- 41016463
- NLM abbreviation
- J Pediatr
- ISSN
- 1097-6833
- eISSN
- 1097-6833
- Publisher
- Elsevier
- Grant note
- Medtronic, USA: MDT220025799 Institutional REDCap Grant: UL1TR0001425 Gerber FoundationMozarc Medical: MDT 220025799
This work was supported in part by Medtronic, USA [MDT220025799] ; Institutional REDCap Grant [UL1TR0001425] . C.L.S. receives in-kind research support (Stavro Medical) and a consultant (Mozarc Medical) . SAB (SeaStar Medical) ; K.G. receives Gerber Foundation funding (MINI-ROCKET study on CRRT nutritional losses/growth in infants <10 kg) ; KOL (Vantive, formerly Baxter) . K.P. receives travel support (Vantive) . J.M. and A.N.S. are consultants (Mozarc Medical, ExThera Medica) . S.L.G. is a consultant/grant funding (Mozarc Medical [MDT 220025799] , Vantive) and a consultant (Vantive, SeaStar) . S.M. receives Gerber Foundation funding (MINI-ROCKET study) and a consultant (Mozarc Medical, Nuwellis, Inc.) . All other authors have no other potential conflicts of interest.
- Language
- English
- Electronic publication date
- 09/26/2025
- Date published
- 01/2026
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984966757602771
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