Journal article
Inflaming the CD8 + T Cell Response
Immunity (Cambridge, Mass.), Vol.25(1), pp.19-29
2006
DOI: 10.1016/j.immuni.2006.07.001
PMID: 16860754
Abstract
Although inflammatory cytokines induced by infection or vaccination with adjuvants have long been known to stimulate optimal antigen-presenting cell function, recent evidence indicates that some inflammatory cytokines also act directly on the responding T cells to control their response to infection. Here, we review the evidence that specific inflammatory cytokines act to control the magnitude of expansion, the degree of contraction, and the rate of memory cell development. These data may suggest new strategies for manipulating vaccine efficacy in the quest to protect against pathogenic microbes.
Details
- Title: Subtitle
- Inflaming the CD8 + T Cell Response
- Creators
- Jodie S Haring - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242Vladimir P Badovinac - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242John T Harty - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.25(1), pp.19-29
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.immuni.2006.07.001
- PMID
- 16860754
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 2006
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047852102771
Metrics
18 Record Views