Inflammasomes in cancer: a double-edged sword

Ryan Kolb; Guang-Hui Liu; Ann M Janowski; Fayyaz S Sutterwala; Weizhou Zhang

doi:10.1007/s13238-013-0001-4

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Inflammasomes in cancer: a double-edged sword

Journal article

Open access

Inflammasomes in cancer: a double-edged sword

Ryan Kolb, Guang-Hui Liu, Ann M Janowski, Fayyaz S Sutterwala and Weizhou Zhang

Protein & cell, Vol.5(1), pp.12-20

01/2014

DOI: 10.1007/s13238-013-0001-4

PMCID: PMC3938856

PMID: 24474192

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Abstract

Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers of interleukin (IL)-1β and IL-18 during inflammation, are large protein complexes typically consisting of a Nod-like receptor (NLR), the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific context. Here we summarize the role of different inflammasome complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and pro-inflammatory cytokines play in immunity.

cancer

Review

inflammation

inflammasome

Details

Title: Subtitle: Inflammasomes in cancer: a double-edged sword
Creators: Ryan Kolb - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 USA
Guang-Hui Liu - National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China
Ann M Janowski - Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 USA
Fayyaz S Sutterwala - Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 USA
Weizhou Zhang - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: Protein & cell, Vol.5(1), pp.12-20
DOI: 10.1007/s13238-013-0001-4
PMID: 24474192
PMCID: PMC3938856
NLM abbreviation: Protein Cell
ISSN: 1674-800X
eISSN: 1674-8018
Publisher: Higher Education Press
Language: English
Date published: 01/2014
Academic Unit: Microbiology and Immunology; Radiation Oncology
Record Identifier: 9984083267102771

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