Journal article
Inflammation and Symptom Change in Interstitial Cystitis or Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study
Urology (Ridgewood, N.J.), Vol.90, pp.56-61
04/2016
DOI: 10.1016/j.urology.2015.12.040
PMCID: PMC4892365
PMID: 26768711
Abstract
To explore inflammatory factors that influence symptom changes in interstitial cystitis or bladder pain syndrome (IC or BPS). This longitudinal, prospective study examined the association of inflammation elicited by Toll-like receptor (TLR) stimulation in peripheral blood mononuclear cells (PBMCs) and diurnal cortisol rhythms with changes in painful and urinary symptoms of IC or BPS and symptom flares over a 48-week period. Participants were 24 women meeting criteria for IC or BPS who supplied blood for isolation of PBMCs and 3 days of salivary cortisol samples prior to a baseline visit. Participants completed the Genitourinary Pain Index (pain and urinary subscales) and reported symptom flares every 2 weeks for 48 weeks. Mixed effects longitudinal and regression models were used to determine if inflammatory variables were associated with the changes in IC or BPS symptoms (time × variable interactions), and the probability of a symptom flare. Elevated TLR-4 inflammation (P = .031) and elevated TLR-2 inflammation (P = .045) from PBMCs, and flattened diurnal cortisol slope (P = .012) were each associated with less improvement in genitourinary pain over time. Additionally, elevated TLR-4 inflammation was associated with less improvement in urinary symptoms (P = .018), whereas TLR-2 inflammation and cortisol slopes were not (both P > .16). In contrast, no inflammatory measure was associated with an increased likelihood of reporting a symptom flare (all P > .25). TLR-mediated inflammation and diurnal cortisol slope may be useful as markers of symptom changes in IC or BPS.
Details
- Title: Subtitle
- Inflammation and Symptom Change in Interstitial Cystitis or Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study
- Creators
- Andrew Schrepf - Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MIMichael A O'Donnell - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IAYi Luo - Department of Urology, University of Iowa, Iowa City, IACatherine S Bradley - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA; Department of Urology, University of Iowa, Iowa City, IAKarl J Kreder - Department of Urology, University of Iowa, Iowa City, IASusan K Lutgendorf - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA; Department of Urology, University of Iowa, Iowa City, IA; Department of Psychological and Brain Science, University of Iowa, Iowa City, IA. Electronic address: Susan-lutgendorf@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Urology (Ridgewood, N.J.), Vol.90, pp.56-61
- DOI
- 10.1016/j.urology.2015.12.040
- PMID
- 26768711
- PMCID
- PMC4892365
- NLM abbreviation
- Urology
- ISSN
- 1527-9995
- eISSN
- 1527-9995
- Publisher
- United States
- Grant note
- U01 DK082344 / NIDDK NIH HHS R01 DK100891 / NIDDK NIH HHS F31 CA177325 / NCI NIH HHS R01DK100891 / NIDDK NIH HHS U01 DK082316 / NIDDK NIH HHS UO1DK082344 / NIDDK NIH HHS K12 DE023574 / NIDCR NIH HHS
- Language
- English
- Date published
- 04/2016
- Academic Unit
- Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9983931745802771
Metrics
21 Record Views