Journal article
Inflammation and human cerebral aneurysms: current and future treatment prospects
Future neurology, Vol.8(6), pp.663-676
11/01/2013
DOI: 10.2217/fnl.13.40
PMCID: PMC3873146
PMID: 24376373
Abstract
The formation of cerebral aneurysms and their rupture propensity is of immediate clinical importance. Current management includes observation with expectant management, microsurgical clipping and/or endovascular coiling. The surgical options are invasive and are not without increased risk despite the technological advances. Recent human and animal studies have shown that inflammation plays a critical role in aneurysm formation and progression to rupture. Modulating this inflammatory process may prove to be clinically significant. This review will discuss cerebral aneurysm pathogenesis with a focus on current and future research of potential use of pharmaceutical agents that attenuate inflammation in the aneurysm wall leading to decreased risk of aneurysm rupture.
Details
- Title: Subtitle
- Inflammation and human cerebral aneurysms: current and future treatment prospects
- Creators
- Joseph S Hudson - University of Iowa, Iowa City IA, USADanielle S Hoyne - Department of Otolaryngology University of Iowa Carver College of Medicine, Iowa City, IA, USADavid M Hasan - Department of Neurosurgery, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
- Resource Type
- Journal article
- Publication Details
- Future neurology, Vol.8(6), pp.663-676
- DOI
- 10.2217/fnl.13.40
- PMID
- 24376373
- PMCID
- PMC3873146
- NLM abbreviation
- Future Neurol
- ISSN
- 1479-6708
- eISSN
- 1748-6971
- Grant note
- R03 NS079227 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Language
- English
- Date published
- 11/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040256802771
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