Inflammation as a Therapeutic Target in Cancer Cachexia

Gerald Clamon; Margaret M. Byrne; Erin E. Talbert

doi:10.3390/cancers14215262

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Inflammation as a Therapeutic Target in Cancer Cachexia

Journal article

Open access

Peer reviewed

Inflammation as a Therapeutic Target in Cancer Cachexia

Gerald Clamon, Margaret M. Byrne and Erin E. Talbert

Cancers, Vol.14(21), p.5262

10/26/2022

DOI: 10.3390/cancers14215262

PMCID: PMC9657920

PMID: 36358681

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https://doi.org/10.3390/cancers14215262View

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Abstract

Cachexia is a common complication of cancer and is associated with poor quality of life and a decrease in survival. Many patients with cancer cachexia suffer from inflammation associated with elevated cytokines, such as interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF). Single-agent trials to treat cancer cachexia have not led to substantial benefit as the type of cytokine which is elevated has rarely been specified and targeted. Cachexia may also be multifactorial, involving inflammation, anorexia, catabolism, depression, and pain, and targeting the multiple causes will likely be necessary to achieve improvement in weight and appetite. A PUBMED search revealed over 3000 articles on cancer cachexia in the past ten years. We attempted to review any studies related to inflammation and cancer cachexia identified by Google Scholar and PUBMED and further search for articles listed in their references. The National Comprehensive Cancer Network (NCCN) guidelines do not provide any suggestion for managing cancer cachexia except a dietary consult. A more targeted approach to developing therapies for cancer cachexia might lead to more personalized and effective therapy.

Cytokines

cancer-associated weight loss

Review

tissue wasting

Details

Title: Subtitle: Inflammation as a Therapeutic Target in Cancer Cachexia
Creators: Gerald Clamon - University of Iowa Hospitals and Clinics
Margaret M. Byrne - University of Iowa
Erin E. Talbert - University of Iowa
Resource Type: Journal article
Publication Details: Cancers, Vol.14(21), p.5262
DOI: 10.3390/cancers14215262
PMID: 36358681
PMCID: PMC9657920
NLM abbreviation: Cancers (Basel)
ISSN: 2072-6694
eISSN: 2072-6694
Publisher: MDPI
Grant note: R00AR071508 / NIH
Language: English
Date published: 10/26/2022
Academic Unit: Molecular Physiology and Biophysics; Hematology, Oncology, and Blood & Marrow Transplantation; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984315588402771

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