Journal article
Inflammation mediates the effect of discrimination, religiosity, and friendship network on expression of the Tp53 cancer suppressor gene
SSM - population health, Vol.7, pp.100389-100389
04/2019
DOI: 10.1016/j.ssmph.2019.100389
PMCID: PMC6503223
PMID: 31080868
Abstract
Chronic inflammation and expression of the
gene are two biomarkers that have been identified as particularly important in the etiology and progression of cancer. While much is known about the determinants of inflammation, there is currently little information regarding the causes of variation in the functioning of
, even though it has been recognized for 40 years as the most potent of the cancer suppressor genes. The current paper explores the interrelationship between these two biomarkers and investigates the extent to which they are influenced by the social environment.
Using structural equation modeling (SEM) and longitudinal observational data from a sample of several hundred African Americans, we tested the hypothesis that adversity - operationalized as racial discrimination- and coping resources - operationalized as religiosity and black friends - influence expression of
, for better or worse, through their impact on inflammation.
Correlational analysis showed inflammation and
to be inversely related. Further, discrimination was positively related to inflammation and negatively related to
expression, whereas religiosity and black friends were both negatively related to inflammation and positively related to
expression. Finally, SEM indicated that the effect of the social environmental variables on
expression was indirect through level of inflammation.
In addition to its established contribution to cancer through DNA damage and cell proliferation, inflammation likely increases cancer risk indirectly by inhibiting expression of the
cancer suppressor gene. Hence environmental and stress management interventions may do more than reduce inflammation's cell damaging effects; they may also lessen the chances of cancer by increasing expression of
.
Details
- Title: Subtitle
- Inflammation mediates the effect of discrimination, religiosity, and friendship network on expression of the Tp53 cancer suppressor gene
- Creators
- Ronald L Simons - Department of Sociology, University of Georgia, Athens, GA 30602, GreeceMan-Kit Lei - Department of Sociology and Center for Family Research, University of Georgia, Athens, GA 30605, GreeceSierra Carter - Department of Psychology, Georgia State University, Atlanta, GA 30303, USASteven R H Beach - Department of Psychology, University of Georgia, Athens GA 30602, GreeceFrederick X Gibbons - Department of Psychological Sciences, University of Connecticut, Storrs, CT 06269, USAMeg Gerrard - Department of Psychological Sciences, University of Connecticut, Storrs, CT 06269, USARobert A Philibert - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- SSM - population health, Vol.7, pp.100389-100389
- DOI
- 10.1016/j.ssmph.2019.100389
- PMID
- 31080868
- PMCID
- PMC6503223
- NLM abbreviation
- SSM Popul Health
- ISSN
- 2352-8273
- eISSN
- 2352-8273
- Publisher
- England
- Grant note
- R21 DA034457 / NIDA NIH HHS R01 MH062668 / NIMH NIH HHS R01 DA021898 / NIDA NIH HHS R01 HL118045 / NHLBI NIH HHS R01 MH062666 / NIMH NIH HHS R01 AG055393 / NIA NIH HHS R01 HD080749 / NICHD NIH HHS R01 DA018871 / NIDA NIH HHS
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003471302771
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