Journal article
Inflammatory Bowel Disease Presenting With Concurrent COVID-19 Multisystem Inflammatory Syndrome
Pediatrics (Evanston), Vol.147(4), p.1
04/01/2021
DOI: 10.1542/peds.2020-027763
PMCID: PMC8015148
PMID: 33414238
Abstract
Coronavirus disease 2019 is associated with a postinfectious multisystem inflammatory syndrome in children (MIS-C). This syndrome is marked by cytokine storm and multiorgan dysfunction, often affecting the gastrointestinal tract, the heart, and the hematopoietic system. We describe the case of a 16-year-old boy with an initial presentation of severe inflammatory bowel disease and concurrent MIS-C. He presented with abdominal pain, diarrhea, and hematochezia and met criteria for the systemic inflammatory response syndrome. Laboratory inflammatory profiling revealed markedly elevated ferritin, D-dimer, C-reactive protein, soluble interleukin 2, and interleukin 6 levels. Endoscopy and colonoscopy revealed severe active gastroduodenitis, patchy colitis, and a normal-appearing terminal ileum. The patient was treated with a combination of steroids, intravenous immunoglobulin, and infliximab, and his symptoms slowly resolved over a 3-week period. In this case, we describe coincident MIS-C with a remarkably severe and difficult-to-treat initial presentation of inflammatory bowel disease and highlight the need to investigate the effect of coronavirus disease 2019 and MIS-C on inflammatory disorders.
COVID-19 MIS-C and its sequelae are still being defined. We present an MIS-C case with concurrent new diagnosis of IBS.
Details
- Title: Subtitle
- Inflammatory Bowel Disease Presenting With Concurrent COVID-19 Multisystem Inflammatory Syndrome
- Creators
- Katherine F. Sweeny - Health FirstYanjia J. Zhang - Health FirstBonnie Crume - Boston Childrens Hosp, Dept Med, Boston, MA 02115 USAColin A. Martz - Boston Childrens Hosp, Dept Med, Boston, MA 02115 USAMelissa M. Blessing - Boston Children's HospitalStacy A. Kahn - Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Boston, MA 02115 USA
- Resource Type
- Journal article
- Publication Details
- Pediatrics (Evanston), Vol.147(4), p.1
- DOI
- 10.1542/peds.2020-027763
- PMID
- 33414238
- PMCID
- PMC8015148
- NLM abbreviation
- Pediatrics
- ISSN
- 0031-4005
- eISSN
- 1098-4275
- Publisher
- Amer Acad Pediatrics
- Number of pages
- 5
- Grant note
- National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32 DK007477 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 04/01/2021
- Academic Unit
- Pathology
- Record Identifier
- 9984755395402771
Metrics
8 Record Views