Journal article
Inflammatory IL-15 is required for optimal memory T cell responses
The Journal of clinical investigation, Vol.125(9), pp.3477-3490
09/01/2015
DOI: 10.1172/JCI81261
PMCID: PMC4588296
PMID: 26241055
Abstract
Due to their ability to rapidly proliferate and produce effector cytokines, memory CD8
+
T cells increase protection following reexposure to a pathogen. However, low inflammatory immunizations do not provide memory CD8
+
T cells with a proliferation advantage over naive CD8
+
T cells, suggesting that cell-extrinsic factors enhance memory CD8
+
T cell proliferation in vivo. Herein, we demonstrate that inflammatory signals are critical for the rapid proliferation of memory CD8
+
T cells following infection. Using murine models of viral infection and antigen exposure, we found that type I IFN–driven expression of IL-15 in response to viral infection prepares memory CD8
+
T cells for rapid division independently of antigen reexposure by transiently inducing cell-cycle progression via a pathway dependent on mTOR complex-1 (mTORC1). Moreover, exposure to IL-15 allowed more rapid division of memory CD8
+
T cells following antigen encounter and enhanced their protective capacity against viral infection. Together, these data reveal that inflammatory IL-15 promotes optimal responses by memory CD8
+
T cells.
Details
- Title: Subtitle
- Inflammatory IL-15 is required for optimal memory T cell responses
- Creators
- Martin J Richer - Department of MicrobiologyLecia L Pewe - Department of MicrobiologyLisa S Hancox - Department of MicrobiologyStacey M Hartwig - Department of MicrobiologySteven M Varga - Department of MicrobiologyJohn T Harty - Department of Microbiology
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.125(9), pp.3477-3490
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI81261
- PMID
- 26241055
- PMCID
- PMC4588296
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 09/01/2015
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984047873102771
Metrics
11 Record Views