Journal article
Inflammatory Myofibroblastic Tumor of the Uterus An Immunohistochemical Study of 23 Cases
The American journal of surgical pathology, Vol.44(11), pp.1441-1449
11/2020
DOI: 10.1097/PAS.0000000000001525
PMID: 32568825
Abstract
Inflammatory myofibroblastic tumors (IMT) of the uterus may be underrecognized as their morphology and immunophenotype may overlap with myxoid variants of uterine smooth muscle tumors and endometrial stromal tumors. Although ALK is a helpful biomarker, not all uterine IMTs areALK-rearranged, and a small subset of myxoid leiomyosarcomas is ALK-positive. Herein, we evaluated a series of 23 IMTs for the novel endometrial stromal markers interferon-inducible transmembrane protein-1 (IFITM1) and BCOR, the novel myoid marker transgelin, and possible predictive markers p16 and p53 by immunohistochemistry to determine their expression profile and potential prognostic value. Patients' ages ranged from 8 to 59 (mean 39) years and tumors from 2 to 20 (mean 8.2) cm. Follow-up was available for 12/23 (52%) patients; 9/12 (75%) without evidence of disease, 2/12 (17%) alive with disease, and 1/12 (8%) dead from disease. Four IMTs were classified as malignant due to extrauterine disease at diagnosis and/or recurrence. IFITM1 was positive (combined score>2) in 19/23 (83%), BCOR in 8/20 (40%), and transgelin in 22/23 (96%) of tumors. IFITM1 and BCOR were more often expressed in the myxoid component, and transgelin in the compact areas. p16 expression was absent in 5/23 (22%) of IMTs, while p53 was wildtype in all tumors. p16-negative IMTs included all 4 classified as malignant and one where the patient was lost to follow-up. Molecular data were available in 2 malignant IMTs, both of which harboredCDKN2Adeletions. We conclude that caution is advised when using IFITM1, BCOR, and transgelin as markers for endometrial and smooth muscle tumors, as these are commonly expressed in IMTs. However, we did identify an association among lack of p16 staining,CKDN2Adeletions, and aggressive behavior that merits corroboration by other studies. As a result of this finding, we recommend the use of p16 in the diagnostic work-up of uterine IMTs due to its potential prognostic significance.
Details
- Title: Subtitle
- Inflammatory Myofibroblastic Tumor of the Uterus An Immunohistochemical Study of 23 Cases
- Creators
- Jennifer A. Bennett - University of ChicagoSabrina Croce - Institut BergoniéAnna Pesci - Ospedale Sacro Cuore Don CalabriaNifang Niu - University of ChicagoKoen Van de Vijver - Cancer Research Institute GhentEric J. Burks - Boston University School of MedicineEike Burandt - Universität HamburgGian Franco Zannoni - Università Cattolica del Sacro CuoreJoseph T. Rabban - University of California, San FranciscoEsther Oliva - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- The American journal of surgical pathology, Vol.44(11), pp.1441-1449
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/PAS.0000000000001525
- PMID
- 32568825
- ISSN
- 0147-5185
- eISSN
- 1532-0979
- Number of pages
- 9
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984701554002771
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