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Inflammatory and vascular correlates of mood change over 8 weeks
Journal article   Open access   Peer reviewed

Inflammatory and vascular correlates of mood change over 8 weeks

Jonathan Birdsall, Samantha Schmitz, Oluchi Abosi, Lyndsey DuBose, Gary Pierce and Jess Fiedorowicz
Heart and Mind, Vol.3(2), pp.47-54
04/01/2019
DOI: 10.4103/hm.hm_24_19
PMCID: PMC7288861
PMID: 32529166
url
https://doi.org/10.4103/hm.hm_24_19View
Published (Version of record) Open Access

Abstract

Background: Mood disorders have been associated with a variety of cardiovascular disease (CVD) risk factors, including inflammation and large arterial stiffness, particularly while depressed, although longitudinal studies have been limited. Materials and Methods: With measurements at baseline and 8 weeks, the researchers prospectively assessed mood, levels of inflammatory markers (high-sensitivity C-reactive protein and tumor necrosis factor-alpha [TNF-α]), serum lipids, and large arterial stiffness in a cohort of 26 participants with a diagnosis of a mood disorder, enriched for current depression. Depressive symptoms were measured using the Montgomery-Šsberg Depression Rating Scale (MADRS) at baseline and 8 weeks. Associations between depressive symptoms and other measures were assessed using linear mixed models, unadjusted and adjusted for age and body mass index. Results: The mean age of the participants (n = 26) was 41.6 (standard deviation [SD] 12.8) years, and 81% were female. During the study, there was a mean (SD) MADRS score improvement of 9.5 (9.4) from baseline to 8 weeks. Reductions in the primary outcome of tumor necrosis factor-α with improvement in depression fell short of statistical significance (P = 0.076). In secondary analyses, there was a statistically significant association between improved cholesterol ratio (P = 0.038) and triglycerides (P = 0.042) with improvement in depression. There was no statistically significant change in large arterial stiffness during the study. Conclusion: Improved depressive symptoms were associated with improved cholesterol ratios even after adjustment, suggesting a possible mechanism by which acute mood states may influence CVD risk. Future longitudinal studies with extended and intensive follow-up investigating CVD risk related to acute changes and persistence of mood symptoms are warranted.
 bipolar disorder lipids mood disorder Arterial stiffness major depressive disorder cardiovascular disease risk inflammation pulse wave velocity

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