Inflammatory biomarkers and spontaneous preterm birth among obese women

Matthew B Wallenstein; Laura L Jelliffe-Pawlowski; Wei Yang; Suzan L Carmichael; David K Stevenson; Kelli K Ryckman; Gary M Shaw

doi:10.3109/14767058.2015.1124083

Journal article

Inflammatory biomarkers and spontaneous preterm birth among obese women

Matthew B Wallenstein, Laura L Jelliffe-Pawlowski, Wei Yang, Suzan L Carmichael, David K Stevenson, Kelli K Ryckman and Gary M Shaw

The Journal of Maternal-Fetal & Neonatal Medicine, Vol.29(20), pp.3317-3322

10/17/2016

DOI: 10.3109/14767058.2015.1124083

PMCID: PMC5108178

PMID: 26700828

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/5108178View

Open Access

Abstract

Objective: To identify associations between second-trimester serum inflammatory biomarkers and preterm birth among obese women. Methods: In this nested case-control study, we compared 65 serum inflammatory biomarkers in obese women whose pregnancies resulted in early spontaneous preterm birth (<32 weeks gestation, n = 34) to obese women whose pregnancies resulted in term birth (n = 34). These women were selected from a larger population-based California cohort. Random forest and classification and regression tree techniques were employed to identify biomarkers of importance, and adjusted odds ratios (aORs) and 95% confidence intervals (CI) were estimated using logistic regression. Results: Random forest and classification and regression tree techniques found that soluble vascular endothelial growth factor receptor-3 (sVEGFR3), soluble interleukin-2 receptor alpha-chain (sIL-2RA) and soluble tumor necrosis factor receptor-1 (sTNFR1) were related to preterm birth. Using multivariable logistic regression to compare preterm cases and term controls, decreased serum levels of sVEGFR3 and increased serum levels of sIL-2RA and sTNFR1 were associated with increased risk of preterm birth among obese women, aOR = 3.2 (95% CI: 1.0-9.9), aOR = 2.8 (95% CI: 0.9-9.0), and aOR = 4.1 (95% CI: 1.2-14.1), respectively. Conclusions: In this pilot study, we identified three serum biomarkers indicative of inflammation to be associated with spontaneous preterm birth among obese women: sVEGFR3, sIL-2RA and sTNFR1.

preterm birth

inflammatory markers

vascular endothelial growth factor

vascular endothelial growth factor receptor-3

soluble interleukin-2 receptor alpha-chain

Inflammation

soluble tumor necrosis factor receptor-1

obesity

Details

Title: Subtitle: Inflammatory biomarkers and spontaneous preterm birth among obese women
Creators: Matthew B Wallenstein - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine
Laura L Jelliffe-Pawlowski - Department of Epidemiology & Biostatistics, UCSF Preterm Birth Initiative, University of California San Francisco School of Medicine
Wei Yang - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine
Suzan L Carmichael - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine
David K Stevenson - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine
Kelli K Ryckman - Department of Epidemiology, University of Iowa
Gary M Shaw - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine
Resource Type: Journal article
Publication Details: The Journal of Maternal-Fetal & Neonatal Medicine, Vol.29(20), pp.3317-3322
DOI: 10.3109/14767058.2015.1124083
PMID: 26700828
PMCID: PMC5108178
NLM abbreviation: J Matern Fetal Neonatal Med
ISSN: 1476-7058
eISSN: 1476-4954
Publisher: Taylor & Francis
Language: English
Date published: 10/17/2016
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983995049602771

Metrics

28 Record Views

18 Times Cited - Web of Science