Journal article
Inflammatory response of mice to manufactured titanium dioxide nanoparticles: Comparison of size effects through different exposure routes
Nanotoxicology, Vol.1(3), pp.211-226
01/01/2007
DOI: 10.1080/17435390701694295
Abstract
TiO
2
is a widely used manufactured nanomaterial and the opportunity for human exposure makes it necessary to study its health implications. Using murine models for inflammation, size effects of inflammatory response in instillation and acute inhalation exposures of TiO
2
nanoparticles with manufacturers' average particles sizes of 5 and 21 nm were investigated. The properties of the primary nanoparticles, nanoparticle agglomerates aerosol and instillation solution for both sized nanoparticles were evaluated. Mice were acutely exposed in a whole-body exposure chamber or through nasal instillation and toxicity was assessed by enumeration of total and differential cells, determination of total protein, LDH activity and inflammatory cytokines in BAL fluid. Lungs were also evaluated for histopathological changes. Results show the larger TiO
2
nanoparticles were found to be moderately, but significantly, more toxic. The nanoparticles had different agglomeration states which may be a factor as important as the surface and physical characteristics of the primary nanoparticles in determining toxicity.
Details
- Title: Subtitle
- Inflammatory response of mice to manufactured titanium dioxide nanoparticles: Comparison of size effects through different exposure routes
- Creators
- Vicki H GrassianAndrea Adamcakova-DoddJohn M PettibonePatrick I O'shaughnessyPeter S Thorne
- Resource Type
- Journal article
- Publication Details
- Nanotoxicology, Vol.1(3), pp.211-226
- Publisher
- Taylor & Francis
- DOI
- 10.1080/17435390701694295
- ISSN
- 1743-5390
- eISSN
- 1743-5404
- Language
- English
- Date published
- 01/01/2007
- Academic Unit
- Chemistry; Civil and Environmental Engineering; Chemical and Biochemical Engineering; Stead Family Department of Pediatrics; Occupational and Environmental Health
- Record Identifier
- 9983997363702771
Metrics
10 Record Views