Journal article
Influence of Age on Calvarial Critical Size Defect Dimensions: A Radiographic and Histological Study
The Journal of craniofacial surgery, Vol.32(8), pp.2896-2900
11/2021
DOI: 10.1097/SCS.0000000000007690
PMCID: PMC8549460
PMID: 33867513
Abstract
Calvarial critical-size defect has been used to assess techniques and materials in the bone regeneration field. Previous studies utilized young adult rats with 3 months of age, which might not reflect the geriatric conditions. This study aimed to assess the dimensions of the calvarial critical-size defect in aged rats. Seventy-two rats in a randomized block design were allocated into a control young adult (11-12 weeks), and a test old group (22-24 months). Both groups were divided according to bone defect's size: 3 mm, 5 mm, and 7 mm defects, which were surgically created and followed for 4 and 8 weeks. Radiographic and histologic analyses were performed. Based on the results, additional groups with 4 mm defect size were added following the same protocols. Young groups yielded higher bone volumes, defect closure percentages, and density of newly formed bone. Closure of cranial defects was only observed in 3 mm defects in both age groups after 8 weeks; however, the 4 mm defect group demonstrated bony bridging after 8 weeks in young but not old rats. Results confirmed that 5-mm defect is considered a critical size for calvarial bone defects in young adult rats; however, 4 mm defect might be considered critical size for the aged rats after 8 weeks.
Details
- Title: Subtitle
- Influence of Age on Calvarial Critical Size Defect Dimensions: A Radiographic and Histological Study
- Creators
- Malik Hudieb - Jordan University of Science and TechnologyAdeeb Haddad - Médecins Sans FrontièresMohammad Bakeer - Médecins Sans FrontièresAhmad Alkhazaaleh - University of Iowa, Operative DentistryMustafa AlKhader - Jordan University of Science and TechnologyDafi Taani - Jordan University of Science and TechnologyShohei Kasugai - Tokyo Medical and Dental University
- Resource Type
- Journal article
- Publication Details
- The Journal of craniofacial surgery, Vol.32(8), pp.2896-2900
- DOI
- 10.1097/SCS.0000000000007690
- PMID
- 33867513
- PMCID
- PMC8549460
- NLM abbreviation
- J Craniofac Surg
- ISSN
- 1049-2275
- eISSN
- 1536-3732
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- 592-2016 / Deanship of Scientific Research at Jordan University of Science and Technology; Jordan University of Science & Technology
- Language
- English
- Date published
- 11/2021
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984949239602771
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