Journal article
Influence of Sex Hormones, HIV Status, and Concomitant Sexually Transmitted Infection on Cervicovaginal Inflammation
The Journal of infectious diseases, Vol.191(3), pp.358-366
02/01/2005
DOI: 10.1086/427190
PMID: 15633094
Abstract
The impact of demographic characteristics, phase of the menstrual cycle, use of hormonal contraceptives, and concomitant lower genital-tract infections on cervicovaginal inflammatory cells was assessed in 967 women, 654 of whom were infected with human immunodeficiency virus type 1 (HIV-1). Cervicovaginal lavage (CVL) fluid was evaluated for total white blood cell (WBC), polymorphonuclear leukocyte, and monocyte counts. HIV-1 infection was not associated with statistically significant differences in numbers of inflammatory cells in CVL fluid except in 1 group—HIV-1-infected women with Chlamydia trachomatis infection had a 0.43 log10 higher WBC count than their HIV-uninfected, chlamydia-positive counterparts (P = .04). Younger age and use of progesterone-based hormonal contraceptives were independently associated with increased numbers of inflammatory cells in CVL fluid. A 0.15–0.2 log10 increase in inflammatory cells was seen in black versus white and Hispanic women after adjustment for known potential confounders. Progesterone-based contraceptives, younger age, and race have an independent effect on cervicovaginal inflammatory cells.
Details
- Title: Subtitle
- Influence of Sex Hormones, HIV Status, and Concomitant Sexually Transmitted Infection on Cervicovaginal Inflammation
- Creators
- Khalil G. Ghanem - Johns Hopkins MedicineNina Shah - Johns Hopkins UniversityRobert S. Klein - Yeshiva UniversityKenneth H. Mayer - Brown UniversityJack D. Sobel - Wayne State UniversityD. L. Warren - Centers for Disease Control and Prevention, Atlanta, GeorgiaDenise J. Jamieson - Centers for Disease Control and PreventionAnn C. Duerr - Centers for Disease Control and PreventionAnne M. Rompalo - Johns Hopkins MedicineHIV Epidemiology Research Study Group
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.191(3), pp.358-366
- DOI
- 10.1086/427190
- PMID
- 15633094
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- The University of Chicago Press
- Language
- English
- Date published
- 02/01/2005
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446516202771
Metrics
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