Journal article
Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium
Circulation (New York, N.Y.), Vol.122(24), pp.2514-2520
12/14/2010
DOI: 10.1161/CIRCULATIONAHA.110.966465
PMID: 21126976
Abstract
Atherosclerosis has its roots in childhood. Therefore, defining the age when childhood risk exposure begins to relate to adult atherosclerosis may have implications for pediatric cardiovascular disease prevention and provide insights about the early determinants of atherosclerosis development. The aim of this study was to investigate the influence of age on the associations between childhood risk factors and carotid artery intima-media thickness, a marker of subclinical atherosclerosis.
We used data for 4380 members of 4 prospective cohorts-Cardiovascular Risk in Young Finns Study (Finland), Childhood Determinants of Adult Health study (Australia), Bogalusa Heart Study (United States), and Muscatine Study (United States)-that have collected cardiovascular risk factor data from childhood (age 3 to 18 years) and performed intima-media thickness measurements in adulthood (age 20 to 45 years). The number of childhood risk factors (high [highest quintile] total cholesterol, triglycerides, blood pressure, and body mass index) was predictive of elevated intima-media thickness (highest decile) on the basis of risk factors measured at age 9 years (odds ratio [95% confidence interval] 1.37 [1.16 to 1.61], P=0.0003), 12 years (1.48 [1.28 to 1.72], P<0.0001), 15 years (1.56 [1.36 to 1.78], P<0.0001), and 18 years (1.57 [1.31 to 1.87], P<0.0001). The associations with risk factors measured at age 3 years (1.17 [0.80 to 1.71], P=0.42) and 6 years (1.20 [0.96 to 1.51], P=0.13) were weaker and nonsignificant.
Our analyses from 4 longitudinal cohorts showed that the strength of the associations between childhood risk factors and carotid intima-media thickness is dependent on childhood age. On the basis of these data, risk factor measurements obtained at or after 9 years of age are predictive of subclinical atherosclerosis in adulthood.
Details
- Title: Subtitle
- Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium
- Creators
- Markus Juonala - Turku University HospitalCostan G MagnussenAlison VennTerence Dwyer - Kliinisen fysiologian ja isotooppilääketieteen yksikköTrudy L BurnsPatricia H DavisWei ChenSathanur R SrinivasanStephen R DanielsMika Kähönen - Kliinisen fysiologian ja isotooppilääketieteen yksikköTomi LaitinenLeena TaittonenGerald S BerensonJorma S A ViikariOlli T Raitakari
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.122(24), pp.2514-2520
- DOI
- 10.1161/CIRCULATIONAHA.110.966465
- PMID
- 21126976
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Grant note
- AG-16592 / NIA NIH HHS RR-00059 / NCRR NIH HHS HL-54730 / NHLBI NIH HHS HL-14230 / NHLBI NIH HHS HL-38844 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/14/2010
- Academic Unit
- Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363636902771
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