Journal article
Influence of body composition on survival in patients with head and neck cancer
Head & neck, Vol.38 Suppl 1(S1), pp.E261-E267
04/2016
DOI: 10.1002/hed.23983
PMID: 25545073
Abstract
Recent evidence has suggested links between obesity and outcomes for various types of cancer. This study investigates the impact that body composition has on survival in patients with head and neck cancer.
Data prospectively collected from 578 patients were analyzed using Cox regression models to determine independent associations that pretreatment body mass index (BMI) and 3-month weight change have on observed survival.
Higher BMIs were associated with better survival (p < .001). Five-year rates ranged from 33.8% for underweight to 75.3% for overweight/obese patients. Patients with stable weight had the highest 5-year rate (72.6%; p = .019), whereas patients who gained ≥5% had worse survival (45.8%) than those who lost ≥5% (65.8%). BMI independently predicted survival, whereas weight change was not an independent predictor.
This demonstrated association between BMI and survival provides useful information when offering prognoses and investigating optimal treatments © 2015 Wiley Periodicals, Inc. Head Neck 38: E261-E267, 2016.
Details
- Title: Subtitle
- Influence of body composition on survival in patients with head and neck cancer
- Creators
- Lucy Hynds Karnell - Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, IowaSteven M Sperry - Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, IowaCarryn M Anderson - Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IowaNitin A Pagedar - Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.38 Suppl 1(S1), pp.E261-E267
- Publisher
- United States
- DOI
- 10.1002/hed.23983
- PMID
- 25545073
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Grant note
- P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 04/2016
- Academic Unit
- Radiation Oncology; Otolaryngology
- Record Identifier
- 9984047863702771
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