Influence of chronic alcoholism and estrogen deficiency on the immunohistochemical expression of regulatory proteins of the bone resorption process in the periodontium of Wistar rats

Adriana Mathias Pereira da Silva Marchini; Gabriela de Fátima Santana-Melo; Miriane Carneiro Machado Salgado; Elis Andrade de Lima Zutin; Leonardo Marchini; Rosilene Fernandes da Rocha; Luana Marotta Reis de Vasconcellos

doi:10.1016/j.archoralbio.2018.07.006

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Influence of chronic alcoholism and estrogen deficiency on the immunohistochemical expression of regulatory proteins of the bone resorption process in the periodontium of Wistar rats

Journal article

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Influence of chronic alcoholism and estrogen deficiency on the immunohistochemical expression of regulatory proteins of the bone resorption process in the periodontium of Wistar rats

Adriana Mathias Pereira da Silva Marchini, Gabriela de Fátima Santana-Melo, Miriane Carneiro Machado Salgado, Elis Andrade de Lima Zutin, Leonardo Marchini, Rosilene Fernandes da Rocha and Luana Marotta Reis de Vasconcellos

Archives of Oral Biology, Vol.95, pp.7-14

11/2018

DOI: 10.1016/j.archoralbio.2018.07.006

PMID: 30031211

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Abstract

Objective: The aim of this study was to investigate possible changes in immunohistochemical expression of proteins regulating the bone resorption process in the periodontium of rats subjected to alcoholism and/or estrogen deficiency. The investigated proteins were receptor activator of nuclear factor-kappa β ligand (RANKL), a protein that stimulates bone resorption, and osteoprotegerin (OPG), a protein that inhibits bone resorption. At the molecular level, decreased OPG expression and/or increased RANKL expression are consistent with a greater predisposition to bone resorption.

Alcohol or Alcoholism

Osteoporosis

Periodontium

ovariectomy

Details

Title: Subtitle: Influence of chronic alcoholism and estrogen deficiency on the immunohistochemical expression of regulatory proteins of the bone resorption process in the periodontium of Wistar rats
Creators: Adriana Mathias Pereira da Silva Marchini - University of Iowa, Preventive and Community Dentistry
Gabriela de Fátima Santana-Melo - Department of Biosciences and Diagnostics, Institute of Science and Technology, UNESP - Univ Estadual Paulista, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, Brazil
Miriane Carneiro Machado Salgado - Department of Biosciences and Diagnostics, Institute of Science and Technology, UNESP - Univ Estadual Paulista, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, Brazil
Elis Andrade de Lima Zutin - Department of Biosciences and Diagnostics, Institute of Science and Technology, UNESP - Univ Estadual Paulista, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, Brazil
Leonardo Marchini - University of Iowa, Preventive and Community Dentistry
Rosilene Fernandes da Rocha - Department of Biosciences and Diagnostics, Institute of Science and Technology, UNESP - Univ Estadual Paulista, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, Brazil
Luana Marotta Reis de Vasconcellos - Department of Biosciences and Diagnostics, Institute of Science and Technology, UNESP - Univ Estadual Paulista, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, Brazil
Resource Type: Journal article
Publication Details: Archives of Oral Biology, Vol.95, pp.7-14
DOI: 10.1016/j.archoralbio.2018.07.006
PMID: 30031211
NLM abbreviation: Arch Oral Biol
ISSN: 0003-9969
eISSN: 1879-1506
Publisher: Elsevier Ltd
Language: English
Date published: 11/2018
Academic Unit: Preventive and Community Dentistry
Record Identifier: 9983763588702771

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