Influence of dietary fat on the enantioselective disposition of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) in female mice

I Kania-Korwel; K.C Hornbuckle; L.W Robertson; H.-J Lehmler

doi:10.1016/j.fct.2007.09.072

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Influence of dietary fat on the enantioselective disposition of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) in female mice

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Influence of dietary fat on the enantioselective disposition of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) in female mice

I Kania-Korwel, K.C Hornbuckle, L.W Robertson and H.-J Lehmler

Food and Chemical Toxicology, Vol.46(2), pp.637-644

2008

DOI: 10.1016/j.fct.2007.09.072

PMCID: PMC2289907

PMID: 17950514

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https://www.ncbi.nlm.nih.gov/pmc/articles/2289907View

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Abstract

Although ingestion is the major route of exposure to polychlorinated biphenyls (PCBs), dietary factors altering their absorption and excretion are only poorly understood. In the present study, (±)-PCB 136 was administered orally to female C57BL/6 mice fed an unrefined (URD, 10% fat) or high fat (HFD, 40% fat) diet to investigate the effect of the dietary fat content on the disposition of PCBs. Three days after administration, PCB levels in the adipose tissue were significantly lower in HFD animals than URD animals, partly due to a higher excretion rate of PCB 136 in the HFD group. (+)-PCB 136 was enriched in all organs and in feces. In both groups, enantiomeric fractions in feces increased each day after administration. We hypothesize that low EF (enantiomeric fraction) values in feces excreted within 24 h of exposure are due to the presence of undigested, racemic PCB. Higher EF values in feces excreted after two and three days are due to excretion of previously absorbed PCBs. Overall, our study suggests that the EF value may be a good tool to investigate the absorption and excretion of PCBs in vivo.

Excretion

Absorption

Polychlorinated biphenyls

Dietary fat

Bioavailability

Feces

Enantiomeric fraction

Details

Title: Subtitle: Influence of dietary fat on the enantioselective disposition of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) in female mice
Creators: I Kania-Korwel - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, #124 IREH, Iowa City, IA 52242, United States
K.C Hornbuckle - Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA, United States
L.W Robertson - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, #124 IREH, Iowa City, IA 52242, United States
H.-J Lehmler - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, #124 IREH, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Food and Chemical Toxicology, Vol.46(2), pp.637-644
DOI: 10.1016/j.fct.2007.09.072
PMID: 17950514
PMCID: PMC2289907
NLM abbreviation: Food Chem Toxicol
ISSN: 0278-6915
eISSN: 1873-6351
Publisher: Elsevier Ltd
Language: English
Date published: 2008
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
Record Identifier: 9983806252902771

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