Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia

J. David SYMONS; Ussama B ZAID; Christian N ATHANASSIOUS; Adam E MULLICK; Steven R LENTZ; John C RUTLEDGE

doi:10.1161/01.ATV.0000204408.01416.16

Back

Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia

Journal article

Open access

Peer reviewed

Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia

J. David SYMONS, Ussama B ZAID, Christian N ATHANASSIOUS, Adam E MULLICK, Steven R LENTZ and John C RUTLEDGE

Arteriosclerosis, thrombosis, and vascular biology, Vol.26(4), pp.814-818

2006

DOI: 10.1161/01.ATV.0000204408.01416.16

PMID: 16424349

Files and links (1)

url

https://doi.org/10.1161/01.ATV.0000204408.01416.16View

Published (Version of record) Open Access

Abstract

Objective: Elevated plasma total homocysteine (tHcy) is associated with risk for cardiovascular disease. A common cause of mild hyperhomocysteinemia (HHcy) is folate deficiency. We sought to determine whether folate deficiency per se increases arterial permeability (quantitative fluorescence microscopy) and stiffness (vessel elastigraph), and whether the effects of folate deficiency are more severe in the presence of mild HHcy. Methods and results: Heterozygous cystathionine beta-synthase (CBS)-deficient mice (CBS(+/-)) and their wild-type littermates (CBS(+/+)) were fed chow containing either standard (Con) or relatively low amounts of folate (LF) for 18+/-3 weeks. Liver folate (microg folate/g liver) and tHcy (microM), respectively, were 12+/-1 and 8+/-1 in CBS(+/+) Con mice (n=12), and 8+/-1 and 8+/-1 in CBS(+/+) LF animals (n=5). Carotid arterial permeability was &38% greater (P<0.05) in CBS(+/+) LF versus Con mice, but vascular stiffening was unaltered. Liver folate and tHcy, respectively, were 13+/-1 and 11+/-1 in CBS(+/-) Con mice (n=16), and 8+/-1 and 16+/-3 in CBS(+/-) LF animals (n=6). Carotid arterial dextran accumulation was &31% greater, and maximal strain in aortae was &20% lower (both P<0.05) in CBS(+/-) LF versus Con mice. Conclusions: Taken together, low folate (P<0.05) combined with mild HHcy (P<0.05) in CBS(+/-) mice produced more arterial dysfunction compared with low folate alone (ie, CBS(+/+) mice). These findings may be particularly relevant to elderly individuals because tHcy and deficiencies of folate metabolism increase with age.

Cardiovascular System

Cardiology. Vascular system

Ultrasonic investigative techniques

Investigative techniques, diagnostic techniques (general aspects)

General and cellular metabolism. Vitamins

Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous

Atherosclerosis (general aspects, experimental research)

Pharmacology. Drug treatments

Biological and medical sciences

Medical sciences

Blood and lymphatic vessels

Details

Title: Subtitle: Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia
Creators: J. David SYMONS - College of Health, University of Utah, Salt Lake City, Utah, United States
Ussama B ZAID - Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California, Davis, Calif, United States
Christian N ATHANASSIOUS - Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California, Davis, Calif, United States
Adam E MULLICK - Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California, Davis, Calif, United States
Steven R LENTZ - Department of Internal Medicine, University of Iowa College of Medicine and Cardiovascular Center, VA Medical Center, Iowa City, Iowa, United States
John C RUTLEDGE - Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California, Davis, Calif, United States
Resource Type: Journal article
Publication Details: Arteriosclerosis, thrombosis, and vascular biology, Vol.26(4), pp.814-818
DOI: 10.1161/01.ATV.0000204408.01416.16
PMID: 16424349
NLM abbreviation: Arterioscler Thromb Vasc Biol
ISSN: 1079-5642
eISSN: 1524-4636
Publisher: Lippincott
Language: English
Date published: 2006
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094533902771

Metrics

31 Record Views

23 Times Cited - Web of Science