Journal article
Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized clinical trial
Journal of clinical periodontology, Vol.50(2), pp.132-146
02/2023
DOI: 10.1111/jcpe.13744
PMCID: PMC10100450
PMID: 36345818
Appears in UI Libraries Support Open Access
Abstract
AIM To evaluate the healing outcomes in non-molar post-extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM-C) as a function of time. MATERIALS AND METHODS Patients in need of non-molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A-3 months; B-6 months; C-9 months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM-C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant-related, and patient-reported outcomes. RESULTSA total of 42 patients completed the study (n = 14 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non-mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient-reported discomfort and wound healing index scores progressively decreased over time and was similar across groups. CONCLUSIONS Healing time influences the proportion of tissue compartments in non-molar post-extraction sites filled with DBBM-C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (≤1 mm) at baseline (Clinicaltrials.gov NCT03659617).
Details
- Title: Subtitle
- Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized clinical trial
- Creators
- Emilio Couso-Queiruga - University of BernHolly A Weber - University of IowaCarlos Garaicoa-Pazmino - University of IowaChristopher Barwacz - University of IowaMarisa Kalleme - University of IowaPablo Galindo-Moreno - Universidad de GranadaGustavo Avila-Ortiz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical periodontology, Vol.50(2), pp.132-146
- DOI
- 10.1111/jcpe.13744
- PMID
- 36345818
- PMCID
- PMC10100450
- NLM abbreviation
- J Clin Periodontol
- eISSN
- 1600-051X
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/501100019921, name: Geistlich Pharma
- Language
- English
- Electronic publication date
- 11/08/2022
- Date published
- 02/2023
- Academic Unit
- Family Dentistry; Periodontics
- Record Identifier
- 9984323339702771
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