Journal article
Influence of low- and high-pressure baroreceptors on plasma renin activity in humans
The American journal of physiology, Vol.235(1), pp.H29-33
07/1978
DOI: 10.1152/ajpheart.1978.235.1.H29
PMID: 677325
Abstract
We evaluated effects of the low- and high-pressure baroreceptors on plasma renin activity (immunoassay) using graded lower body suction (LBS) in six healthy men. LBS at -10 and -20 mmHg for 10 min decreased central venous pressure without changing arterial pressure and thereby presumably reduced low- but not high-pressure baroreceptor inhibition of renin release. LBS at these levels produced forearm vasoconstriction, but did not increase renin. LBS at -40 mmHg decreased central venous and arterial pulse pressure and thus reduced both low- and high-pressure baroreceptor inhibition. LBS at this level produced forearm vasoconstriction and tachycardia and increased renin from 2.1 +/- 0.4 (mean +/- SE to 7.4 +/- 1.4 ng.ml-1.h-1 (P less than 0.05). In summary, reduction in low-pressure baroreceptor inhibition in humans did not increase renin in the presence of physiological tonic inhibition from high-pressure baroreceptors. Increases in renin did not occur until there was combined reduction of high- and low-pressure baroreceptor inhibition on plasma renin activity.
Details
- Title: Subtitle
- Influence of low- and high-pressure baroreceptors on plasma renin activity in humans
- Creators
- Allyn L MarkFrancois M AbboudAnnette E Fitz
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.235(1), pp.H29-33
- DOI
- 10.1152/ajpheart.1978.235.1.H29
- PMID
- 677325
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Publisher
- United States
- Language
- English
- Date published
- 07/1978
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025349102771
Metrics
19 Record Views