Journal article
Influence of the Cardiac Sympathetics on Left Ventricular Dynamics during Tachycardia
Cardiology, Vol.58(6), pp.326-334
1973
DOI: 10.1159/000169650
PMID: 4154066
Abstract
Increasing heart rate by atrial pacing in conscious, resting dogs resulted in declines in stroke volume (-0.40 ml/beat-kg/100 beats/min; p < 0.001), and left ventricular transverse internal diameter at end-diastole (-3.40 mm/100 beats/min; p < 0.001) and end-systole (-2.14 mm/100 beats/min; p < 0.001). When pacing was repeated following β-adrenergic blockade, stroke volume declined slightly more than had occurred during the control response. The decrease in end-diastolic diameter was -2.13 mm/100 beats/min while the end-systolic diameter declined at a rate of -0.93 mm/100 beats/min. It is concluded that loss of β-adrenergic tone limits stroke volume at high heart rates due to a diminished ability of the myocardium to shorten, as indicated by elevation in the left ventricular end-systolic diameter.
Details
- Title: Subtitle
- Influence of the Cardiac Sympathetics on Left Ventricular Dynamics during Tachycardia
- Creators
- Vernon S. BishopLawrence D. Horwitz
- Resource Type
- Journal article
- Publication Details
- Cardiology, Vol.58(6), pp.326-334
- DOI
- 10.1159/000169650
- PMID
- 4154066
- ISSN
- 0008-6312
- eISSN
- 1421-9751
- Number of pages
- 9
- Language
- English
- Date published
- 1973
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656532702771
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